衣藻鞭毛α-微管蛋白的翻译后修饰在鞭毛吸收过程中发生逆转。
Reversal of the posttranslational modification on Chlamydomonas flagellar alpha-tubulin occurs during flagellar resorption.
作者信息
L'Hernault S W, Rosenbaum J L
出版信息
J Cell Biol. 1985 Feb;100(2):457-62. doi: 10.1083/jcb.100.2.457.
Abstract
We previously have shown that a posttranslational modification of alpha-tubulin takes place in the flagellum during Chlamydomonas flagellar assembly (L'Hernault, S. W., and J. L. Rosenbaum, 1983, J. Cell Biol., 97:258-263). In this report, we show that the posttranslationally modified alpha-3 tubulin is changed back to its unmodified alpha-1 precursor form during the microtubular disassembly that takes place during flagellar resorption. These data indicate that the addition and removal of a posttranslational modification on alpha-tubulin might be a control step in the assembly and disassembly of flagella.
摘要
我们之前已经表明，在衣藻鞭毛组装过程中，α-微管蛋白的翻译后修饰发生在鞭毛中（L'Hernault, S. W., 和J. L. Rosenbaum, 1983, 《细胞生物学杂志》, 97:258 - 263）。在本报告中，我们表明，在鞭毛吸收过程中发生的微管解聚期间，翻译后修饰的α-3微管蛋白会变回其未修饰的α-1前体形式。这些数据表明，α-微管蛋白翻译后修饰的添加和去除可能是鞭毛组装和解聚的一个控制步骤。
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