Georganas Alexandros, Graziosi Giulia, Catelli Elena, Lupini Caterina
Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, BO, Italy.
Animals (Basel). 2024 Nov 28;14(23):3453. doi: 10.3390/ani14233453.
subsp. serovar Infantis poses a growing threat to public health, due to its increasing prevalence worldwide and its association with high levels of antimicrobial resistance. Among livestock, Infantis is especially isolated from broilers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted by searching in three databases (Web of Science, Scopus, and PubMed) for English-language studies (1957-2023) that reported the prevalence of Infantis in broiler farms. Eligible studies included epidemiological investigations conducted in broiler chickens by sampling the house environment (flock-level prevalence) or the birds (individual-level prevalence). A random-effect model was applied to calculate Infantis pooled prevalence estimates with 95% confidence intervals (CIs). Furthermore, to assess between-study heterogeneity, the inconsistency index statistic (I) was calculated. Among 537 studies retrieved, a total of 9 studies reporting flock-level prevalence of Infantis and 4 reporting individual-level prevalence were retained for analysis. The flock-level pooled prevalence was estimated to be 9% (95% CI: 1-26%) and a high between-study heterogeneity was found (I = 99%, < 0.01). Concerning individual-level prevalence, a meta-analysis was not performed due to the scarcity of eligible studies. The data presented underscore the significant occurrence of Infantis in broilers at the farm level. By summarizing the existing literature, this work provides useful insights for conducting future surveys of spp. in live broiler chickens as a preliminary step for developing more efficient control strategies.
婴儿亚种血清型对公共卫生构成了日益严重的威胁，这是由于其在全球范围内的患病率不断上升以及与高水平的抗菌药物耐药性相关联。在牲畜中，婴儿亚种尤其常见于肉鸡。按照系统评价和荟萃分析的首选报告项目（PRISMA）指南，通过在三个数据库（科学网、Scopus和PubMed）中检索1957年至2023年期间报告肉鸡场中婴儿亚种患病率的英文研究，进行了一项系统评价。符合条件的研究包括通过对鸡舍环境（鸡群水平患病率）或鸡只（个体水平患病率）进行采样，对肉鸡进行的流行病学调查。应用随机效应模型计算婴儿亚种合并患病率估计值及其95%置信区间（CIs）。此外，为了评估研究间的异质性，计算了不一致指数统计量（I）。在检索到的537项研究中，总共保留了9项报告婴儿亚种鸡群水平患病率的研究和4项报告个体水平患病率的研究进行分析。鸡群水平的合并患病率估计为9%（95%CI：1-26%），并且发现研究间存在高度异质性（I=99%，<0.01）。关于个体水平患病率，由于符合条件的研究较少，未进行荟萃分析。所呈现的数据强调了婴儿亚种在农场层面肉鸡中的显著存在。通过总结现有文献，这项工作为今后对活肉鸡中该亚种进行调查提供了有用的见解，作为制定更有效控制策略的初步步骤。
