USDA, ARS, National Animal Disease Center, Food Safety and Enteric Pathogens Research Unit, Ames, IA, United States.
USDA, ARS, National Animal Disease Center, Food Safety and Enteric Pathogens Research Unit, Ames, IA, United States.
Vaccine. 2024 Feb 6;42(4):727-731. doi: 10.1016/j.vaccine.2023.12.054. Epub 2024 Jan 13.
Human foodborne outbreaks with antibiotic-resistant Salmonella enterica associated with contaminated poultry products have recently involved serogroup C serovars Infantis and Hadar. The current study evaluated a commercially available Salmonella vaccine for cross-protection against Infantis and Hadar serovars in turkeys. The live, attenuated S. Typhimurium (serogroup B) vaccine significantly reduced colonization of intestinal tissues (cecum, cecal tonsils, and cloaca) by serovars Infantis (C1) and Hadar (C2) and significantly limited systemic dissemination to the spleen. S. Infantis, but not S. Hadar, disseminated to bone marrow in non-vaccinated turkeys, but vaccination prevented S. Infantis dissemination to the bone marrow. The S. Infantis challenge strain contained the pESI megaplasmid, and virulence mechanism(s) residing on this plasmid may support dissemination and/or colonization of systemic niches such as myeloid tissue. Collectively, the data indicate that vaccinating turkeys with the serogroup B S. Typhimurium vaccine limited intestinal colonization and systemic dissemination by serogroup C serovars Infantis and Hadar.
人类食源性耐药性沙门氏菌肠炎感染爆发与受污染的家禽产品有关，最近涉及血清群 C 的婴儿血清型和哈达尔血清型。本研究评估了一种市售的沙门氏菌疫苗，以针对火鸡中的婴儿血清型和哈达尔血清型提供交叉保护。活的、减毒的鼠伤寒沙门氏菌（血清群 B）疫苗显著减少了肠道组织（盲肠、盲肠扁桃体和泄殖腔）中婴儿血清型（C1）和哈达尔血清型（C2）的定植，并且显著限制了向脾脏的全身传播。沙门氏菌婴儿血清型，但不是哈达尔血清型，会在未接种疫苗的火鸡中传播到骨髓，但接种疫苗可防止沙门氏菌婴儿血清型传播到骨髓。婴儿血清型挑战株含有 pESI 大型质粒，而这种质粒上的毒力机制可能支持骨髓等全身生态位的传播和/或定植。总的来说，数据表明，用血清群 B 鼠伤寒沙门氏菌疫苗接种火鸡可限制血清群 C 血清型婴儿血清型和哈达尔血清型的肠道定植和全身传播。
