Haskey Natasha, Eisele Maximillian, Bruno Andreina, Reimer Raylene A, Yousuf Munazza, Taylor Lorian M, Panaccione Remo, Ghosh Subrata, Raman Maitreyi
Department of Medicine, Cumming School of Medicine, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.
Department of Biology, Irving K Barber Faculty of Science, University of British Columbia-Okanagan, 3137 University Way, Kelowna, BC V1V 1V7, Canada.
Diagnostics (Basel). 2024 Nov 22;14(23):2629. doi: 10.3390/diagnostics14232629.
The disruption of the intestinal epithelial barrier leads to increased intestinal permeability (IP), allowing endotoxins and pathogens to enter the bloodstream contributing to chronic inflammation. Western diets are associated with increased IP, while diets rich in polyphenols, fiber, and omega-3 fats are linked to decreased IP. The relationship between diet, disease activity, and IP in ulcerative colitis (UC) is poorly understood. We evaluated the effects of serum zonulin and lipopolysaccharide-binding protein (LBP) and their relationship to dietary factors in UC. A cross-sectional analysis was conducted on 37 UC participants who had baseline measures of dietary intake, disease activity and serum. Serum LBP and zonulin levels were measured by ELISA. Spearman's rank correlations explored relationships between baseline IP, diet, and disease activity. The median age was 35 years (29-47 years), 54% were male, and 76% were in clinical remission or had mild disease activity (partial Mayo score ≤ 4). LBP was significantly correlated ( < 0.05) with disease activity (partial Mayo score (r = 0.31), and positively correlated with total fat (r = 0.42) and refined grains (r = 0.35), but negatively correlated with fruit consumption (r = -0.50) and diet quality (r = -0.33). Zonulin was negatively correlated with protein (r = -0.39), niacin (r = -0.52) and vitamin B12 (r = -0.45) with a trend for significance ( = 0.06) with body mass index (r = 0.32). Baseline LBP levels were correlated with disease activity markers and dietary factors, suggesting that it could be a useful biomarker for assessing disease activity and diet quality in UC. Further trials are needed to confirm these findings.
肠道上皮屏障的破坏会导致肠道通透性（IP）增加，使内毒素和病原体进入血液，从而引发慢性炎症。西方饮食与IP增加有关，而富含多酚、纤维和ω-3脂肪酸的饮食则与IP降低有关。溃疡性结肠炎（UC）患者的饮食、疾病活动与IP之间的关系尚不清楚。我们评估了血清连蛋白和脂多糖结合蛋白（LBP）的作用及其与UC饮食因素的关系。对37名UC参与者进行了横断面分析，这些参与者有饮食摄入量、疾病活动和血清的基线测量值。通过酶联免疫吸附测定法（ELISA）测量血清LBP和连蛋白水平。Spearman等级相关性分析探讨了基线IP、饮食和疾病活动之间的关系。中位年龄为35岁（29 - 47岁），54%为男性，76%处于临床缓解期或疾病活动较轻（部分梅奥评分≤4）。LBP与疾病活动（部分梅奥评分（r = 0.31））显著相关（<0.05），与总脂肪（r = 0.42）和精制谷物（r = 0.35）呈正相关，但与水果摄入量（r = -0.50）和饮食质量（r = -0.33）呈负相关。连蛋白与蛋白质（r = -0.39）、烟酸（r = -0.52）和维生素B12（r = -0.45）呈负相关，与体重指数（r = 0.32）有显著趋势（= 0.06）。基线LBP水平与疾病活动标志物和饮食因素相关，表明它可能是评估UC疾病活动和饮食质量的有用生物标志物。需要进一步的试验来证实这些发现。
