Grigore Raluca, Bejenaru Paula Luiza, Berteșteanu Gloria Simona, Nedelcu-Stancalie Ruxandra Ioana, Schipor-Diaconu Teodora Elena, Rujan Simona Andreea, Taher Bianca Petra, Berteșteanu Șerban Vifor Gabriel, Popescu Bogdan, Popescu Irina Doinița, Nicolaescu Alexandru, Cîrstea Anca Ionela, Simion-Antonie Catrinel Beatrice
Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Otorhinolaryngology Department, "Colțea" Clinical Hospital, 030171 Bucharest, Romania.
Curr Oncol. 2025 Jun 30;32(7):379. doi: 10.3390/curroncol32070379.
: Quality of life (QoL) is a critical indicator in assessing the success of oncological treatments for head and neck malignancies, reflecting their impact on physiological functions and psychosocial well-being beyond mere survival. Treatments (surgery, radiotherapy, chemotherapy) pose multiple functional and emotional challenges, and recent advancements underscore the necessity of evaluating post-treatment QoL. : This literature review investigates the impact of oncological treatment on the QoL of patients with malignant head and neck cancers (oral, oropharyngeal, hypopharyngeal, laryngeal) and identifies factors influencing their QoL index. : Using a PICO framework, studies from PubMed Central were analyzed, selected based on inclusion (English publications, full text, PROM results) and exclusion criteria. The last research was conducted on 6 April 2025. From 231 identified studies, 49 were included after applying filters (MeSH: "Quality of Life," "laryngeal cancer," "oral cavity cancer," etc.). Data were organized in Excel, and the methodology adhered to PRISMA standards. : Treatment Impact: Oncological treatments significantly affect QoL, with acute post-treatment declines in functions such as speech, swallowing, and emotional well-being (anxiety, depression). Partial recovery depends on rehabilitative interventions. Influencing Factors: Treatment type, disease stage, socioeconomic, and demographic contexts influence QoL. De-escalated treatments and prompt rehabilitation improve recovery, while complications like trismus, dysphagia, or persistent hearing issues reduce long-term QoL. Assessment Tools: Standardized PROM questionnaires (EORTC QLQ-C30, QLQ-H&N35, MDADI, HADS) highlighted QoL variations. Studies from Europe, North America, and Asia indicate regional differences in outcomes. : Retrospective designs, small sample sizes, and PROM variability limit generalizability. Multicentric studies with extended follow-up are recommended. : Oncological treatments for head and neck malignancies have a complex impact on QoL, necessitating personalized and multidisciplinary strategies. De-escalated therapies, early rehabilitation, and continuous monitoring are essential for optimizing functional and psychosocial outcomes. Methodological gaps highlight the need for standardized research.
生活质量（QoL）是评估头颈部恶性肿瘤肿瘤治疗成功与否的关键指标，反映了这些治疗对生理功能和心理社会幸福感的影响，而不仅仅是生存情况。治疗方法（手术、放疗、化疗）带来了多种功能和情感挑战，最近的进展凸显了评估治疗后生活质量的必要性。
本文献综述调查了肿瘤治疗对头颈部恶性肿瘤（口腔、口咽、下咽、喉）患者生活质量的影响，并确定了影响其生活质量指数的因素。
使用PICO框架，对来自PubMed Central的研究进行了分析，根据纳入标准（英文出版物、全文、患者报告结局结果）和排除标准进行筛选。最后一次研究于2025年4月6日进行。在231项已识别的研究中，应用筛选条件后纳入了49项（医学主题词：“生活质量”、“喉癌”、“口腔癌”等）。数据在Excel中进行整理，方法遵循PRISMA标准。
肿瘤治疗显著影响生活质量，治疗后短期内言语、吞咽和情感幸福感（焦虑、抑郁）等功能会下降。部分恢复取决于康复干预措施。
治疗类型、疾病阶段、社会经济和人口背景会影响生活质量。降级治疗和及时康复可改善恢复情况，而诸如牙关紧闭、吞咽困难或持续性听力问题等并发症会降低长期生活质量。
标准化的患者报告结局问卷（欧洲癌症研究与治疗组织生活质量核心问卷QLQ-C30、头颈部癌问卷QLQ-H&N35、MD安德森吞咽困难问卷MDADI、医院焦虑抑郁量表HADS）突出了生活质量的差异。来自欧洲、北美和亚洲的研究表明结果存在地区差异。
回顾性设计、小样本量和患者报告结局的变异性限制了研究结果的普遍性。建议开展多中心研究并进行长期随访。
头颈部恶性肿瘤的肿瘤治疗对生活质量有复杂的影响，需要个性化和多学科策略。降级治疗、早期康复和持续监测对于优化功能和心理社会结局至关重要。方法学上的差距凸显了标准化研究的必要性。
