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表面功能化氧化铜纳米颗粒：医疗器械中多药耐药病原体控制的途径。

Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices.

作者信息

Hall James, Mekapothula Subbareddy, Coxhill Rebecca, Craske Dominic, Varney Adam M, Cave Gareth W V, McLean Samantha

机构信息

School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK.

出版信息

Nanomaterials (Basel). 2024 Nov 26;14(23):1899. doi: 10.3390/nano14231899.

DOI:10.3390/nano14231899
PMID:39683288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643601/
Abstract

Copper oxide nanoparticles (CuONPs) offer promising antimicrobial properties against a range of pathogens, addressing the urgent issue of antibiotic resistance. This study details the synthesis of glutamic acid-coated CuONPs (GA-CuONPs) and their functionalisation on medical-grade silicone tubing, using an oxysilane bonding agent. The resulting coating shows significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains, while remaining non-toxic to human cells and exhibiting stable adherence, without leaching. This versatile coating method can be applied during manufacturing, or for ad hoc modifications, enhancing the antimicrobial properties of medical devices.

摘要

氧化铜纳米颗粒（CuONPs）对一系列病原体具有良好的抗菌性能，解决了抗生素耐药性这一紧迫问题。本研究详细介绍了谷氨酸包覆的CuONPs（GA-CuONPs）的合成及其使用氧基硅烷粘合剂在医用级硅胶管上的功能化。所得涂层对革兰氏阳性菌和革兰氏阴性菌均表现出显著的抗菌活性，包括多重耐药菌株，同时对人类细胞无毒且具有稳定的附着力，不会浸出。这种通用的涂层方法可在制造过程中应用，或用于临时改性，增强医疗设备的抗菌性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/98383ae45c19/nanomaterials-14-01899-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/b01bff8a06da/nanomaterials-14-01899-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/af54123a80f3/nanomaterials-14-01899-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/95a4b3f4b79d/nanomaterials-14-01899-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/796770152e50/nanomaterials-14-01899-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/98383ae45c19/nanomaterials-14-01899-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/b01bff8a06da/nanomaterials-14-01899-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/af54123a80f3/nanomaterials-14-01899-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/95a4b3f4b79d/nanomaterials-14-01899-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/796770152e50/nanomaterials-14-01899-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6eb/11643601/98383ae45c19/nanomaterials-14-01899-g005.jpg

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