Tabor Elżbieta, Górczyńska-Kosiorz Sylwia, Pluskiewicz Wojciech, Gumprecht Janusz
Department of Internal Medicine, Diabetology and Nephrology Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Metabolic Bone Diseases Unit, Department of Internal Medicine, Diabetology and Nephrology Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Nutrients. 2024 Nov 29;16(23):4146. doi: 10.3390/nu16234146.
The clinical significance of the genetic influence of vitamin D receptor polymorphisms has still not been well-analyzed.
To verify whether rs1544410, rs7975232 and rs731236 polymorphisms are associated with a higher 10-year fracture risk in postmenopausal women.
The study group was a subset of a pre-defined population as part of the broader epidemiological research called the RAC-OST-POL Study and consisted of 358 postmenopausal women, chosen randomly from Racibórz (Poland) inhabitants (mean baseline age 65 ± 6.9 years, BMI 31.2 ± 5.5 kg/m). From all participants' medical history, data concerning co-morbidities, fracture history, the medication used, parental history of bone fractures, cigarettes and alcohol use were taken at baseline. Moreover, rs1544410, rs7975232 and rs731236 polymorphisms were analyzed. Next, over the following 10 years, participants were contacted once a year and questioned concerning new fractures events and their circumstances.
We did not find statistically significant main effects on the fracture incidence of single-polymorphism variants. However, there were some significant findings dependent on the co-existence of these polymorphisms and medical factors. Women with a positive history of parental fracture and configuration of CC rs7975232, AA rs731236 and CC rs1544410 had a higher fracture incidence. The risk of bone fracture was also significantly higher in the group of heterozygotes of AC rs7975232 if their BMI value was in the categories of normal weight or overweight, or if they were treated with calcium or vitamin D.
Polymorphisms of rs1544410, rs7975232 and rs731236 are connected with the fracture incidence in postmenopausal women. Nevertheless, its influence should be considered with co-existing clinical factors, especially paternal fracture history, prior fracture, BMI value, any osteoporotic treatment or calcium/vit. D supplementation.
维生素D受体多态性的遗传影响的临床意义尚未得到充分分析。
验证rs1544410、rs7975232和rs731236多态性是否与绝经后女性10年骨折风险增加相关。
研究组是一项名为RAC - OST - POL研究的更广泛流行病学研究中预先定义人群的一个子集，由358名绝经后女性组成，她们是从波兰拉齐布日的居民中随机挑选的（平均基线年龄65±6.9岁，体重指数31.2±5.5kg/m）。在基线时，从所有参与者的病史中获取有关合并症、骨折史、使用的药物、父母骨折史、吸烟和饮酒情况的数据。此外，对rs1544410、rs7975232和rs731236多态性进行了分析。接下来，在随后的10年中，每年与参与者联系一次，询问新的骨折事件及其情况。
我们没有发现单多态性变体对骨折发生率有统计学上的显著主要影响。然而，有一些显著发现取决于这些多态性和医学因素的共存。有父母骨折阳性史且rs7975232为CC型、rs731236为AA型和rs1544410为CC型的女性骨折发生率较高。如果rs7975232的杂合子AC组女性的体重指数值处于正常体重或超重类别，或者她们接受了钙或维生素D治疗，其骨折风险也显著更高。
rs1544410、rs7975232和rs731236多态性与绝经后女性的骨折发生率有关。然而，其影响应与共存的临床因素一起考虑，特别是父亲骨折史、既往骨折、体重指数值、任何骨质疏松治疗或钙/维生素D补充剂。
