Song W O, Wyse B W, Hansen R G
J Am Diet Assoc. 1985 Feb;85(2):192-8.
Pantothenic acid nutritional status was evaluated longitudinally in 26 pregnant women (experimental group) during their third trimester of pregnancy and at 2 weeks and 3 months postpartum. Seventeen nonpregnant and nonlactating women (control group) participated at the same time intervals. All the women were assessed by the intake calculated from a reported 2-day dietary record and by fasted blood, plasma, and 24-hour urinary levels of pantothenate determined by a radioimmunoassay. Estimated daily mean dietary pantothenate intake and the vitamin density for the experimental group were not statistically different from those for the control group. The dietary pantothenate intake averaged 2.75 mg/1,000 kcal. Average pantothenate blood level of the experimental group was lower than that of the control group. No significant difference was found between the two groups in the pantothenate levels of fasting plasma and urinary excretion. When they did not take pantothenic acid supplements, members of the experimental group had intakes less than the Estimated Safe and Adequate Daily Dietary Intake and lower mean blood values than the members of the control group. This suggests that pregnant and lactating women need to consume more pantothenate to maintain a blood vitamin level similar to that of nonpregnant women. This may be achieved by an increased caloric intake, if desirable, or by more careful selection of foods high in the nutrient.
对26名孕妇（实验组）在妊娠晚期以及产后2周和3个月时的泛酸营养状况进行了纵向评估。17名非孕非哺乳期妇女（对照组）在相同时间间隔参与评估。所有妇女均通过根据2天饮食记录报告计算的摄入量以及通过放射免疫测定法测定的空腹血液、血浆和24小时尿泛酸盐水平进行评估。实验组估计的每日平均膳食泛酸盐摄入量和维生素密度与对照组相比无统计学差异。膳食泛酸盐摄入量平均为2.75毫克/1000千卡。实验组的平均泛酸盐血液水平低于对照组。两组在空腹血浆泛酸盐水平和尿排泄方面未发现显著差异。当实验组的成员不服用泛酸补充剂时，其摄入量低于估计的每日安全和充足膳食摄入量，且平均血液值低于对照组的成员。这表明怀孕和哺乳期妇女需要摄入更多的泛酸以维持与非怀孕妇女相似的血液维生素水平。如果需要，可以通过增加热量摄入或更仔细地选择富含该营养素的食物来实现这一点。
