Comprehensive Review on Fruit of : Traditional Uses, Phytochemistry, Pharmacology, Toxicity, and Pharmacokinetics.

Retz., known for its dried fruit, namely Chebulae Fructus, is a medicinal plant with a long-standing global reputation, which was initially recognized for its therapeutic properties during the Jin Dynasty. This review consolidates current knowledge on the traditional uses, phytochemistry, pharmacological properties, toxicity, and pharmacokinetics of Chebulae Fructus, highlighting its clinical significance and the promising therapeutic potential of its compounds. To date, studies have identified approximately 149 compounds within the plant, including tannins, phenolic acids, lignans, triterpenes, flavonoids, and volatiles. These compounds confer a broad spectrum of biological activities in vitro and in vivo, such as antioxidant, anti-inflammatory, antiviral, anticancer, antibacterial, hepatoprotective, nephroprotective, neuroprotective, and anti-diabetic, some of which are already integrated into clinical practice. However, despite substantial advancements, considerable gaps remain in understanding the complete mechanisms of action, pharmacokinetics, and safety profiles of its extracts and compounds. This paper advocates for enhanced focus on these areas to fully elucidate the therapeutic capacities and facilitate the clinical application of Chebulae Fructus. This comprehensive analysis not only reinforces the ethnopharmacological significance of Chebulae Fructus but also lays a foundation for future pharmacological explorations.