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用于结直肠癌治疗的二氧化硅纳米颗粒设计：最新进展与临床潜力

Silica nanoparticle design for colorectal cancer treatment: Recent progress and clinical potential.

作者信息

Meng Jin, Wang Zhi-Gang, Zhao Xiu, Wang Ying, Chen De-Yu, Liu De-Long, Ji Cheng-Chun, Wang Tian-Fu, Zhang Li-Mei, Bai Hai-Xia, Li Bo-Yang, Liu Yuan, Wang Lei, Yu Wei-Gang, Yin Zhi-Tao

机构信息

Department of Anorectal Disease, Shenyang Coloproctology Hospital, Shenyang 110000, Liaoning Province, China.

Acupuncture and Tuina College, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China.

出版信息

World J Clin Oncol. 2024 Jun 24;15(6):667-673. doi: 10.5306/wjco.v15.i6.667.

DOI:10.5306/wjco.v15.i6.667
PMID:38946830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11212613/
Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide and the second most common cause of cancer death. Nanotherapies are able to selectively target the delivery of cancer therapeutics, thus improving overall antitumor efficiency and reducing conventional chemotherapy side effects. Mesoporous silica nanoparticles (MSNs) have attracted the attention of many researchers due to their remarkable advantages and biosafety. We offer insights into the recent advances of MSNs in CRC treatment and their potential clinical application value.

摘要

结直肠癌（CRC）是全球第三大常见癌症，也是癌症死亡的第二大常见原因。纳米疗法能够选择性地靶向递送癌症治疗药物，从而提高整体抗肿瘤效率并减少传统化疗的副作用。介孔二氧化硅纳米颗粒（MSNs）因其显著的优势和生物安全性而吸引了众多研究人员的关注。我们深入探讨了MSNs在CRC治疗中的最新进展及其潜在的临床应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11212613/745683ec5455/WJCO-15-667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11212613/745683ec5455/WJCO-15-667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11212613/745683ec5455/WJCO-15-667-g001.jpg

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Colorectal cancer statistics, 2023.2023 年结直肠癌统计数据。
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Therapeutic Targets and Tumor Microenvironment in Colorectal Cancer.结直肠癌的治疗靶点与肿瘤微环境
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Multifunctional biomolecule nanostructures for cancer therapy.用于癌症治疗的多功能生物分子纳米结构。
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