Ohtake Shinji, Kawahara Takashi, Ishiguro Yukari, Takeshima Teppei, Kuroda Shinnosuke, Izumi Koji, Miyamoto Hiroshi, Uemura Hiroji
Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.
Department of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan.
Mol Clin Oncol. 2018 Sep;9(3):302-304. doi: 10.3892/mco.2018.1665. Epub 2018 Jul 3.
Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG. All cases expressed 8-OHdG. The levels of 8-OHdG expression in prostatic cancer (30.0% moderate and 70.0% strong) were significantly higher than those in benign prostatic hyperplasia (71.4% moderate and 28.6% strong; (p<0.01). Notably, 8-OHdG is expressed more highly in prostate cancer tissues in comparison to benign prostate tissues.
氧化应激是血管内皮损伤的主要原因。在前列腺中，缺血会增加活性氧、生长因子和细胞因子的水平，并诱导血管生成的发展，从而导致癌症进展。比较了前列腺癌组织和非肿瘤性前列腺组织中氧化应激标志物8-羟基鸟苷（8-OHdG）的表达水平。对由10例前列腺腺癌和70例良性前列腺增生组成的前列腺组织芯片进行8-OHdG免疫组织化学染色。所有病例均表达8-OHdG。前列腺癌中8-OHdG的表达水平（30.0%为中度，70.0%为强阳性）显著高于良性前列腺增生（71.4%为中度，28.6%为强阳性；p<0.01）。值得注意的是，与良性前列腺组织相比，8-OHdG在前列腺癌组织中的表达更高。
