Riquelme-Aguado Víctor, Di-Bonaventura Silvia, González-Álvarez María Elena, Zabarte-Del Campo Alazne, Fernández-Carnero Josué, Gil-Crujera Antonio, Gómez-Esquer Francisco, Villafañe Jorge Hugo
Department of Basic Health Sciences, Rey Juan Carlos University, 28933 Madrid, Spain.
Grupo de Investigación Consolidado de Bases Anatómicas, Moleculares y del Desarrollo Humano de la Universidad Rey Juan Carlos (GAMDES), 28922 Alcorcón, Spain.
J Clin Med. 2024 Dec 2;13(23):7339. doi: 10.3390/jcm13237339.
: Fibromyalgia syndrome (FMS) is a multifactorial pain syndrome not only characterized by widespread pain as the primary symptom but also accompanied by physical, psychological, and cognitive manifestations. Impairments in conditioned pain modulation (CPM) are common in this population; however, there is significant heterogeneity in the CPM response among women with FMS. The Left/Right Judgment Task (LRJT) is a validated method for studying motor imagery in chronic pain patients. Previous scientific evidence has not yet thoroughly investigated the relationship between CPM alterations and motor imagery processes in FMS patients. The aim of this study was to investigate the relationship between CPM and motor imagery. : This is a secondary analysis of a cross-sectional study. Pain intensity (NPRS), disability (FIQ), mechanical hyperalgesia (PPT), descending pain modulation (CPM), and laterality discrimination (LRJT) were assessed in 30 women diagnosed with FMS. Participants were divided into two groups, responder and non-responder, according to their response to the CPM test. : Findings showed that the FMS subgroup of non-responders to CPM, performed worse in motor imagery processes (LRJT). Additionally, older age and higher mechanical hyperalgesia were also associated with poorer functioning of the inhibitory system. : Women with FMS who are non-responders to CPM exhibit a reduced ability to perform motor imagery processes. Additionally, the non-responder group shown significant differences, such as older age and greater initial mechanical hyperalgesia compared to the responder group.
纤维肌痛综合征（FMS）是一种多因素疼痛综合征，不仅以广泛疼痛为主要症状，还伴有身体、心理和认知表现。条件性疼痛调制（CPM）受损在该人群中很常见；然而，FMS女性患者的CPM反应存在显著异质性。左右判断任务（LRJT）是研究慢性疼痛患者运动想象的一种有效方法。以前的科学证据尚未彻底研究FMS患者中CPM改变与运动想象过程之间的关系。本研究的目的是调查CPM与运动想象之间的关系。：这是一项横断面研究的二次分析。对30名被诊断为FMS的女性进行了疼痛强度（NPRS）、残疾程度（FIQ）、机械性痛觉过敏（PPT）、下行性疼痛调制（CPM）和方向辨别（LRJT）评估。根据参与者对CPM测试的反应，将其分为反应者和无反应者两组。：研究结果表明，CPM无反应者的FMS亚组在运动想象过程（LRJT）中表现较差。此外，年龄较大和机械性痛觉过敏程度较高也与抑制系统功能较差有关。：CPM无反应的FMS女性表现出运动想象能力下降。此外，与反应者组相比，无反应者组存在显著差异，如年龄较大和初始机械性痛觉过敏程度更高。
