Nithuthorn Chalisa, Chaipichit Natapohn, Jeeraaumponwat Thammasorn, Maiprasert Mart, Dilokthornsakul Piyameth
Department of Anti-Aging and Regenerative Medicine College of Integrative Medicine, Dhurakij Pundit University, Laksi, Bangkok 10210, Thailand.
Center for Medical and Health Technology Assessment (CM-HTA), Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
J Clin Med. 2024 Dec 6;13(23):7447. doi: 10.3390/jcm13237447.
Pilates is one of the non-pharmacological interventions for fibromyalgia (FM). However, its impacts on pain and health-related quality of life (HRQOL) in fibromyalgia patients (FMPs) are inconclusive. This study aimed to assess the effects of Pilates on pain and HRQOL among FMPs. A systematic review and meta-analysis were conducted. Four databases-PubMed, ScienceDirect, Scopus, and Cochrane CENTRAL-along with one grey literature source, Google Scholar, were searched for randomized controlled trials comparing Pilates with other exercises or usual care in FMPs. The outcomes were pain and HRQOL. A meta-analysis was performed using a random-effects model. Six studies were included = 265). We found that the effects of Pilates from each individual study on pain were inconsistent. Our pooled analysis of visual analog scale (VAS) scores demonstrated significant pain reduction (mean difference (MD), -0.71, 95%CI, -1.33 to -0.10, = 0.023; ( = 29.3%, = 0.226)). However, neither the algometric score (AS) nor tender point count (TPC) showed an insignificant difference (AS: MD, -0.43, 95%CI, -2.60 to 1.74, = 0.700; ( = 0.0%, = 0.654); TPC: MD, -0.16, 95%CI, -2.22 to 1.89, = 0.520; ( = 0.0%, = 0.515)). Regarding HRQOL, Pilates showed statistically significant improvements on the Fibromyalgia Impact Questionnaire (FIQ) (MD, -7.28, 95%CI, (-12.06 to -2.49), = 0.003; ( = 95.7%, < 0.001)). A sensitivity analysis of three RCTs ( = 176) based on the ACR 2010 supported this finding (MD, -7.68, 95% CI, -8.60 to -6.76, < 0.001; ( = 0.0% 0.832)) with non-important heterogeneity. Pilates may benefit FMPs. It could reduce pain and improve HRQOL. Given the small number of studies and the presence of data heterogeneity, future high-quality RCTs would provide a clearer conclusion.
普拉提是纤维肌痛（FM）的非药物干预措施之一。然而，其对纤维肌痛患者（FMPs）疼痛及健康相关生活质量（HRQOL）的影响尚无定论。本研究旨在评估普拉提对FMPs疼痛和HRQOL的影响。进行了一项系统评价和荟萃分析。检索了四个数据库——PubMed、ScienceDirect、Scopus和Cochrane CENTRAL——以及一个灰色文献来源Google Scholar，以查找比较普拉提与其他运动或常规护理对FMPs影响的随机对照试验。结局指标为疼痛和HRQOL。使用随机效应模型进行荟萃分析。纳入了六项研究（n = 265）。我们发现，每项个体研究中普拉提对疼痛的影响并不一致。我们对视觉模拟量表（VAS）评分的汇总分析显示疼痛显著减轻（平均差（MD），-0.71，95%CI，-1.33至-0.10，P = 0.023；I² = 29.3%，P = 0.226）。然而，压痛计评分（AS）和压痛点计数（TPC）均未显示出显著差异（AS：MD，-0.43，95%CI，-2.60至1.74，P = 0.700；I² = 0.0%，P = 0.654；TPC：MD，-0.16，95%CI，-2.22至1.89，P = 0.520；I² = 0.0%，P = 0.515）。关于HRQOL，普拉提在纤维肌痛影响问卷（FIQ）上显示出统计学上的显著改善（MD，-7.28，95%CI，（-12.06至-2.49），P = 0.003；I² = 95.7%，P < 0.001）。基于美国风湿病学会（ACR）2010版对三项随机对照试验（n = 176）的敏感性分析支持了这一发现（MD，-7.68，95%CI，-8. .60至-6.76，P < 0.001；I² = 0.0%，P = 0.832），且异质性不显著。普拉提可能使FMPs受益。它可以减轻疼痛并改善HRQOL。鉴于研究数量较少且存在数据异质性，未来高质量的随机对照试验将提供更明确的结论。
