Chen Lan, Xu Fan, Tong Qian, Wang Guofu
Zhejiang Hospital, Hangzhou, Zhejiang, China.
Dongxiang Hospital of Traditional Chinese Medicine, Fuzhou, Jiangxi, China.
Medicine (Baltimore). 2024 Dec 13;103(50):e40946. doi: 10.1097/MD.0000000000040946.
Our previous studies suggested that bone mineral density (BMD) correlated with the severity of chronic heart failure (HF) as classified by the New York Heart Association (NYHA) and that blood routine test (BRT)-based biomarkers, including hemoglobin, red blood cells (RBCs), lymphocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index, were significantly related with BMD in general population.
This work aimed to evaluate the relationship between BRT-based biomarkers and BMD in elderly patients with chronic HF.
It was a retrospective study. BRT and BMD were measured on the same day. Chi-square analysis and 1-way analysis of variance or the Wilcoxon rank-sum test were used to compare categorical variables and continuous variables, respectively. Correlation analysis was performed by the Spearman correlation test.
A total of 1049 participants were enrolled. Hemoglobin, RBCs, white blood cells, neutrophils, monocytes, eosinophils, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index were significantly different among different NYHA groups. The Spearman correlation test showed that lumbar vertebrae 2-4 (L2-L4) BMD was closely related to hemoglobin and RBC, and that femoral neck BMD was also significantly correlated with hemoglobin and RBC, white blood cells, neutrophils, monocytes, and platelets. Furthermore, stratified analysis in different NYHA classes demonstrated, only in NYHA class I and II groups, hemoglobin was significantly related to L2-L4 and femoral neck BMD.
BRT-based biomarkers were significantly different among different NYHA groups, which deserves further investigation and application in the future.
我们之前的研究表明，骨密度（BMD）与纽约心脏协会（NYHA）分类的慢性心力衰竭（HF）严重程度相关，并且在普通人群中，基于血常规检查（BRT）的生物标志物，包括血红蛋白、红细胞（RBC）、淋巴细胞、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、淋巴细胞与单核细胞比值以及全身免疫炎症指数，与骨密度显著相关。
本研究旨在评估老年慢性心力衰竭患者中基于BRT的生物标志物与骨密度之间的关系。
这是一项回顾性研究。在同一天测量BRT和BMD。分别采用卡方分析和单因素方差分析或Wilcoxon秩和检验来比较分类变量和连续变量。通过Spearman相关检验进行相关性分析。
共纳入1049名参与者。不同NYHA组之间的血红蛋白、RBC、白细胞、中性粒细胞、单核细胞、嗜酸性粒细胞、淋巴细胞与单核细胞比值以及全身免疫炎症指数存在显著差异。Spearman相关检验显示，第2 - 4腰椎（L2 - L4）骨密度与血红蛋白和RBC密切相关，股骨颈骨密度也与血红蛋白、RBC、白细胞、中性粒细胞、单核细胞和血小板显著相关。此外，在不同NYHA分级中的分层分析表明，仅在NYHA I级和II级组中，血红蛋白与L2 - L4和股骨颈骨密度显著相关。
不同NYHA组之间基于BRT的生物标志物存在显著差异，这在未来值得进一步研究和应用。
