中性粒细胞与淋巴细胞比值与绝经后妇女骨密度的关系：系统评价和荟萃分析。

Association of neutrophil to lymphocyte ratio with bone mineral density in post-menopausal women: a systematic review and meta-analysis.

机构信息

Bone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Geriatric & Gerontology Department, Medical School, Tehran University of medical and health sciences, Tehran, Iran.

出版信息

BMC Womens Health. 2024 Mar 9;24(1):169. doi: 10.1186/s12905-024-03006-1.

DOI:10.1186/s12905-024-03006-1

PMID:38461235

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10924380/

Abstract

BACKGROUND

We conducted a systematic review and meta-analysis to compare the neutrophil lymphocyte ratio (NLR) levels between women with post-menopausal osteopenia or osteoporosis to those with normal bone mineral density (BMD).

METHODS

We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 19, 2022, only in English language. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Newcastle-Ottawa scale for quality assessment.

RESULTS

Overall, eight articles were included in the analysis. Post-menopausal women with osteoporosis had elevated levels of NLR compared to those without osteoporosis (SMD = 1.03, 95% CI = 0.18 to 1.88, p = 0.017, I = 98%). In addition, there was no difference between post-menopausal women with osteopenia and those without osteopenia in neutrophil lymphocyte ratio (NLR) levels (SMD = 0.58, 95% CI=-0.08 to 1.25, p = 0.085, I = 96.8%). However, there was no difference between post-menopausal women with osteoporosis and those with osteopenia in NLR levels (SMD = 0.75, 95% CI=-0.01 to 1.51, p = 0.05, I = 97.5%, random-effect model).

CONCLUSION

The results of this study point to NLR as a potential biomarker that may be easily introduced into clinical settings to help predict and prevent post-menopausal osteoporosis.

摘要

背景

我们进行了一项系统评价和荟萃分析，比较了绝经后骨质疏松症或骨量减少的女性与正常骨密度（BMD）的女性之间的中性粒细胞淋巴细胞比值（NLR）水平。

方法

我们使用 Web of Science、PubMed 和 Scopus 进行了系统搜索，以查找截至 2022 年 6 月 19 日之前发表的仅以英文发表的相关文献。我们报告了标准化均数差（SMD）及其 95%置信区间（CI）。由于存在显著的异质性，我们使用随机效应模型计算了合并效应。我们使用纽卡斯尔-渥太华量表进行质量评估。

结果

总体而言，有八项研究纳入了分析。与无骨质疏松症的女性相比，患有骨质疏松症的绝经后女性 NLR 水平升高（SMD=1.03，95%CI=0.18 至 1.88，p=0.017，I=98%）。此外，患有骨量减少的绝经后女性与无骨量减少的女性之间的 NLR 水平无差异（SMD=0.58，95%CI=-0.08 至 1.25，p=0.085，I=96.8%）。然而，患有骨质疏松症的绝经后女性与患有骨量减少的女性之间的 NLR 水平无差异（SMD=0.75，95%CI=-0.01 至 1.51，p=0.05，I=97.5%，随机效应模型）。