Khadembashiri Mohammad Amin, Mohseni Shahrzad, Aghakhani Amirhossein, Khalagi Kazem, Mansourzadeh Mohammad Javad, Pejman Sani Mahnaz, Mohajeri-Tehrani Mohammadreza, Farzadfar Farshad, Fahimfar Noushin, Ostovar Afshin
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Arch Osteoporos. 2025 Feb 5;20(1):18. doi: 10.1007/s11657-025-01507-6.
UNLABELLED: The associations between serum hemoglobin (Hb) levels and bone mineral density (BMD) were investigated in population of the 4th Iranian Multicenter Osteoporosis Study (IMOS). A positive relationship between Hb levels and BMD at hip and femoral neck were detected only in men. PURPOSE: Previous studies have investigated the relationship between hemoglobin (Hb) levels and bone mineral density (BMD) with controversial findings. This study aimed to evaluate this association using data from the 4th Iranian Multicenter Osteoporosis Study (IMOS), a population-based national survey, including a population sample aged 50 years and older. METHODS: The present study was conducted as a cross-sectional data analysis derived from the fourth round of the IMOS. Demographic information, Hb levels, and BMD measurements were collected. BMD was measured with dual-energy X-ray absorptiometry (DXA). Low BMD (osteopenia/osteoporosis) and osteoporosis were defined as a T-score less than -1 and less than -2.5 at each site including hip, femoral neck, or lumbar spine, respectively. Multiple linear regression analysis was used to assess the relationship between Hb levels and BMD. RESULTS: This study included 1,426 participants (54.2% female) with the mean age of 62.6 ± 8.0 years. The mean Hb levels among patients with or without osteoporosis were 12.9 ± 2.0 mg/dl and 13.1 ± 1.9 mg/dl, respectively (p-value = 0.08). It was demonstrated a positive relationship between Hb levels and BMD at hip (β = 0.0079, 95% CI: 0.002- 0.0135, p-value = 0.006) and femoral neck (β = 0.0064, 95% CI: 0.0015- 0.0113, p-value = 0.01) in only men. However, there was no significant correlation between Hb levels with low BMD and osteoporosis in either gender. CONCLUSION: Our findings showed a favorable relationship between Hb levels and BMD at the hip and femoral neck, particularly in men. This highlights gender and site-specific distinctions between hematological and skeletal health..Future studies should unravel these possible associations and investigate the underlying mechanisms.
未标注：在第四届伊朗多中心骨质疏松症研究（IMOS）人群中，研究了血清血红蛋白（Hb）水平与骨密度（BMD）之间的关联。仅在男性中检测到Hb水平与髋部和股骨颈骨密度之间存在正相关关系。 目的：先前的研究调查了血红蛋白（Hb）水平与骨密度（BMD）之间的关系，但结果存在争议。本研究旨在利用第四届伊朗多中心骨质疏松症研究（IMOS）的数据评估这种关联，该研究是一项基于人群的全国性调查，包括50岁及以上的人群样本。 方法：本研究作为从IMOS第四轮数据中得出的横断面数据分析进行。收集了人口统计学信息、Hb水平和骨密度测量值。采用双能X线吸收法（DXA）测量骨密度。低骨密度（骨量减少/骨质疏松症）和骨质疏松症分别定义为髋部、股骨颈或腰椎每个部位的T值小于-1和小于-2.5。采用多元线性回归分析评估Hb水平与骨密度之间的关系。 结果：本研究纳入了1426名参与者（54.2%为女性），平均年龄为62.6±8.0岁。有或无骨质疏松症患者的平均Hb水平分别为12.9±2.0mg/dl和13.1±1.9mg/dl（p值=0.08）。仅在男性中显示Hb水平与髋部骨密度（β=0.0079，95%CI：0.002-0.0135，p值=0.006）和股骨颈骨密度（β=0.0064，95%CI：0.0015-0.0113，p值=0.01）之间存在正相关关系。然而，无论男性还是女性，Hb水平与低骨密度和骨质疏松症之间均无显著相关性。 结论：我们的研究结果显示Hb水平与髋部和股骨颈骨密度之间存在良好的关系，尤其是在男性中。这突出了血液学和骨骼健康在性别和部位上的特定差异。未来的研究应阐明这些可能的关联并探究其潜在机制。
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