Kose Oguz, Sarac Gul Yagmur, Altin Ahmet, Bostan Semih Alperen, Faiz Ozlem, Akyildiz Kerimali, Yilmaz Adnan
Department of Periodontology, School of Dentistry, Recep Tayyip Erdogan University, Rize, Turkey.
Department of Periodontology, School of Dentistry, Istanbul Kent University, Istanbul, Turkey.
Int J Dent Hyg. 2025 Aug;23(3):482-490. doi: 10.1111/idh.12890. Epub 2024 Dec 17.
In this clinical study, chlorhexidine gluconate (CHX) was chosen as the positive control group, and the clinical and biochemical efficacy of mouthwashes with green tea, white tea and essential oil (EO) as the active ingredients were aimed to be examined comprehensively.
A total of 112 participants with gingivitis were randomly assigned to four different groups and different mouthwashes were used for 4 weeks: CHX-MW group (as a positive control group), EO-MW group, GT-MW group and WT-MW group. The effects of the mouthwashes on plaque, inflammation and dental staining were evaluated by indexed scores at the beginning and 4th week. Markers related to gingival inflammation and oxidative stress were evaluated on samples from the gingival crevicular fluid.
In the 4th week, significant improvements in clinical parameters were found in all groups (p < 0.05) with the more pronounced improvement in the CHX-MW group (p < 0.05). However, only the CHX caused a significant discolouration of both teeth and tongue (p < 0.05). The levels of IL-1β and MMP-8 were found to be lower in all groups compared to the first measurements (p < 0.05). Furthermore, the antioxidant effect of EO mouthwash was found significantly low compared to the other three mouthwashes (p < 0.05).
Green and white tea extracts provided clinical benefits in the short term (1 month) with no statistical difference from each other and mouthwash with EO as the active ingredient while they provided a lower clinical benefit compared to CHX. Products with tea as the active ingredient may be an alternative to EO mouthwash for short-term and long-term use.
在本临床研究中，选择葡萄糖酸氯己定（CHX）作为阳性对照组，旨在全面检测以绿茶、白茶和精油（EO）为活性成分的漱口水的临床和生化疗效。
总共112名牙龈炎参与者被随机分为四组，使用不同的漱口水4周：CHX-MW组（作为阳性对照组）、EO-MW组、GT-MW组和WT-MW组。在第1周和第4周通过指数评分评估漱口水对牙菌斑、炎症和牙齿染色的影响。对龈沟液样本中与牙龈炎症和氧化应激相关的标志物进行评估。
在第4周时，所有组的临床参数均有显著改善（p < 0.05），CHX-MW组改善更为明显（p < 0.05）。然而，只有CHX导致牙齿和舌头明显变色（p < 0.05）。与首次测量相比，所有组中白细胞介素-1β（IL-1β）和基质金属蛋白酶-8（MMP-8）的水平均较低（p < 0.05）。此外，与其他三种漱口水相比，EO漱口水的抗氧化作用显著较低（p < 0.05）。
绿茶和白茶提取物在短期内（1个月）具有临床益处，彼此之间以及与以EO为活性成分的漱口水相比无统计学差异，不过与CHX相比临床益处较低。以茶为活性成分的产品可能是短期和长期使用EO漱口水的替代品。
