Nag Deb Sanjay, Varghese Koshy, Swain Amlan, Patel Roushan, Sahu Seelora, Sam Merina
Department of Anaesthesiology, Tata Main Hospital, Jamshedpur 831001, Jharkhand, India.
Department of Anaesthesiology, Manipal Tata Medical College, Jamshedpur 831017, India.
World J Clin Cases. 2024 Dec 16;12(35):6754-6759. doi: 10.12998/wjcc.v12.i35.6754.
Obstructive sleep apnea (OSA) is often a lifestyle disease associated with obesity, which is rapidly evolving as a major health concern with diverse multisystemic implications. To prevent and mitigate its adverse effects and reduce its burden on society, its aetiopathogeneses must be precisely understood. Numerous studies focusing on the range of diverse anatomic, functional, and lifestyle factors have already been carried out to determine the possible contributory roles of these factors in OSA. Recently, evidence to validate the role of inflammatory pathways and immune mechanisms in the aetiopathogeneses of OSA is being developed. This allows for further research and translation of such knowledge for targeted therapeutic and preventive interventions in patients with or who are at risk of developing OSA.
阻塞性睡眠呼吸暂停（OSA）通常是一种与肥胖相关的生活方式疾病，肥胖正迅速演变成一个主要的健康问题，具有多种多系统影响。为了预防和减轻其不良影响并减轻其对社会的负担，必须准确了解其发病机制。已经开展了许多针对各种解剖、功能和生活方式因素的研究，以确定这些因素在阻塞性睡眠呼吸暂停中可能的促成作用。最近，正在积累证据以证实炎症途径和免疫机制在阻塞性睡眠呼吸暂停发病机制中的作用。这使得能够进一步研究此类知识并将其转化为针对阻塞性睡眠呼吸暂停患者或有患阻塞性睡眠呼吸暂停风险的人的靶向治疗和预防干预措施。
