Suo Meng, Zhang Tianfu, Liang Xing-Jie
School of Biomedical Engineering, The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou 510260, People's Republic of China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, People's Republic of China.
Prog Biomed Eng (Bristol). 2024 Dec 17;7(1). doi: 10.1088/2516-1091/ad9aeb.
Since the concept of aggregation-induced emission (AIE) was first coined by Tang and co-workers, AIE-active luminogens (AIEgens) have drawn widespread attention among chemists and biologists due to their unique advantages such as high fluorescence efficiency, large Stokes shift, good photostability, low background noise, and high biological visualization capabilities in the aggregated state, surpassing conventional fluorophores. A growing number of AIEgens have been engineered to possess multifunctional properties, including near-infrared emission, two-photon absorption, reactive oxygen species (ROS) generation and photothermal conversion, making them suitable for deep-tissue imaging and phototherapy. AIEgens show great potential in biomedical applicationsand. However, despite the favorable photophysical stability and ROS/heat generation capability in the aggregated state, limitations including uncontrolled size, low targeting efficiency, and unexpected dispersion in physiological environments have hindered their biomedical applications. The combination of AIEgens with lipids offers a simple, promising, and widely adopted solution to these challenges. This review article provides an overview of the synthesis methods of AIEgen-lipid nanostructures and their applications in the biomedical engineering field, aiming to serve as a guideline for developing these AIEgens-lipid nanostructures with promising biological applications.
自从唐本忠及其同事首次提出聚集诱导发光（AIE）的概念以来，具有聚集诱导发光活性的发光体（AIEgens）因其独特优势，如高荧光效率、大斯托克斯位移、良好的光稳定性、低背景噪音以及在聚集态下具有高生物可视化能力，超越了传统荧光团，从而在化学家和生物学家中引起了广泛关注。越来越多的AIEgens被设计成具有多功能特性，包括近红外发射、双光子吸收、活性氧（ROS）生成和光热转换，使其适用于深部组织成像和光疗。AIEgens在生物医学应用中显示出巨大潜力。然而，尽管在聚集态下具有良好的光物理稳定性和ROS/热量生成能力，但包括尺寸不可控、靶向效率低以及在生理环境中意外分散等局限性阻碍了它们的生物医学应用。将AIEgens与脂质相结合为应对这些挑战提供了一种简单、有前景且被广泛采用的解决方案。这篇综述文章概述了AIEgen-脂质纳米结构的合成方法及其在生物医学工程领域的应用，旨在为开发具有前景生物应用的这些AIEgens-脂质纳米结构提供指导。
