Gomes Claudia, Barreto Mariana Nicolielo, Sousa Anaíde Silva, Reis Dayane Guerino, Beirigo Priscila, Reis Izadora, Fauth Caroline, Belo Andrea, Park Hanna, Tavares Ana Luiza, Munhoz Livia, Alegretti José Roberto, Chéles Dóris S, Lorenzon Aline R
Clinical Department, Huntington Centro de Medicina Reprodutiva - Eugin Group, São Paulo, SP, Brazil.
Embryology Laboratory, Huntington Centro de Medicina Reprodutiva - Eugin Group, São Paulo, SP, Brazil.
JBRA Assist Reprod. 2025 Mar 12;29(1):191-194. doi: 10.5935/1518-0557.20240072.
Natural conception in women after the age of 45 years is rare. The probability of successful pregnancy in this specific group of women after IVF and embryo transfer with autologous oocytes is also reduced. In addition, advanced maternal age is associated with an increased risk of aneuploidies and other associated complications during pregnancy. Generally, women who are over 44 years old are advised to receive IVF treatment with donated oocytes due to poor oocyte quality and low ovarian reserve. Although IVF outcomes in women of advanced age can be associated with the best prognosis when donated oocytes are used, IVF is not always well accepted by infertile couples. This is a case report of a woman who achieved a clinical pregnancy and live birth in her first attempt at IVF treatment with her own eggs and a euploid embryo at 48 years and 10 months, respectively, at the time of oocyte retrieval. This case demonstrates that limited attempts at assisted reproductive technology with older women's own eggs may be an option in specific cases.
45岁以上女性自然受孕的情况很少见。对于这一特定群体的女性，在使用自体卵母细胞进行体外受精（IVF）和胚胎移植后成功怀孕的概率也会降低。此外，高龄产妇在孕期发生非整倍体及其他相关并发症的风险会增加。一般来说，由于卵母细胞质量差和卵巢储备低，建议44岁以上的女性接受使用捐赠卵母细胞的IVF治疗。尽管对于高龄女性，使用捐赠卵母细胞进行IVF治疗时其结果可能具有最佳预后，但IVF并非总能被不孕夫妇所接受。本文报告了一例48岁10个月的女性，在取卵时分别使用自己的卵子和一个整倍体胚胎进行首次IVF治疗，成功实现临床妊娠并分娩活婴。该病例表明，在特定情况下，对高龄女性使用其自身卵子进行有限次数的辅助生殖技术尝试可能是一种选择。
