基于核脂质调节的阿尔茨海默病星形胶质细胞病变的潜在治疗方法。 - Suppr

Potential treatment of Alzheimer's disease astrocyte pathology based on nuclear lipid regulation.

作者信息

Komai Masato, Takasugi Nobumasa

机构信息

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

出版信息

Neural Regen Res. 2026 Jan 1;21(1):322-323. doi: 10.4103/NRR.NRR-D-24-01125. Epub 2024 Dec 16.

DOI:10.4103/NRR.NRR-D-24-01125

PMID:39688557

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12094534/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d32d/12094534/26ecd58ac325/NRR-21-322-g001.jpg

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Potential treatment of Alzheimer's disease astrocyte pathology based on nuclear lipid regulation.基于核脂质调节的阿尔茨海默病星形胶质细胞病变的潜在治疗方法。

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Astrocyte and oligodendrocyte pathology in Alzheimer's disease.阿尔茨海默病中的星形胶质细胞和少突胶质细胞病理学

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Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia-astrocyte communication in Alzheimer's disease.脑脊液β2-微球蛋白通过阿尔茨海默病中小胶质细胞-星形胶质细胞通讯促进tau病理改变。

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Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles.血清胶质纤维酸性蛋白（GFAP）水平与星形胶质细胞反应性、死后脑萎缩及神经原纤维缠结相关。

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High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization.高强度间歇训练通过调节星形胶质细胞表型相关的 AQP4 极化改善阿尔茨海默病样病理。

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Distinct cytokine profiles in human brains resilient to Alzheimer's pathology.对阿尔茨海默病具有抗性的人脑存在独特的细胞因子特征。

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Effects of amyloid β (Aβ)42 and Gasdermin D on the progression of Alzheimer's disease and through the regulation of astrocyte pyroptosis.淀粉样蛋白 β（Aβ）42 和 Gasdermin D 通过调节星形胶质细胞焦亡对阿尔茨海默病的进展的影响。

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本文引用的文献

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation.鞘氨醇激酶 2 调节芳香烃受体核易位和靶基因激活。

Adv Sci (Weinh). 2024 Oct;11(40):e2400794. doi: 10.1002/advs.202400794. Epub 2024 Aug 29.

The advent of Alzheimer treatments will change the trajectory of human aging.阿尔茨海默病治疗方法的出现将改变人类衰老的轨迹。

Nat Aging. 2024 Apr;4(4):453-463. doi: 10.1038/s43587-024-00611-5. Epub 2024 Apr 19.

Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes.核 SphK2/S1P 信号是星形胶质细胞中 ApoE 产生和 Aβ摄取的关键调节因子。

J Lipid Res. 2024 Mar;65(3):100510. doi: 10.1016/j.jlr.2024.100510. Epub 2024 Jan 26.

Astrocytes as Neuroimmunocytes in Alzheimer's Disease: A Biochemical Tool in the Neuron-Glia Crosstalk along the Pathogenetic Pathways.星形胶质细胞作为阿尔茨海默病中的神经免疫细胞：沿着发病途径的神经元-胶质细胞串扰中的生化工具。

Int J Mol Sci. 2023 Sep 9;24(18):13880. doi: 10.3390/ijms241813880.

The Pursuit of the "Inside" of the Amyloid Hypothesis-Is C99 a Promising Therapeutic Target for Alzheimer's Disease?淀粉样假说之“内”在探索——C99 是阿尔茨海默病有希望的治疗靶点吗？

Cells. 2023 Jan 31;12(3):454. doi: 10.3390/cells12030454.

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.鞘氨醇激酶 2 增强淀粉样蛋白沉积，但可预防阿尔茨海默病小鼠模型中海马体积丢失和脱髓鞘。

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.

Single-cell transcriptomic analysis of Alzheimer's disease.阿尔茨海默病的单细胞转录组分析。

Nature. 2019 Jun;570(7761):332-337. doi: 10.1038/s41586-019-1195-2. Epub 2019 May 1.

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.神经鞘氨醇激酶 2 在阿尔茨海默病脑中的亚细胞定位发生改变。

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Potential treatment of Alzheimer's disease astrocyte pathology based on nuclear lipid regulation.

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