Hamlyn A N, Hopper J C, Skillen A W
Clin Chim Acta. 1979 Aug 1;95(3):453-9. doi: 10.1016/0009-8981(79)90196-7.
An enzyme temporarily depressed by alcohol ingestion, erythrocyte delta-aminolaevulinate dehydratase (delta-ALAD), was compared with afternoon casual blood ethanol and plasma gamma-glutamyltransferase (gamma-glutamyltransferase (gamma-GT) simultaneously measured in outpatients. These comprised 37 individuals with chronic alcoholism, of whom 14 had severe liver disease, 22 patients with non-alcoholic liver disease and 24 healthy control subjects. All tests distinguished poorly between those alcoholics with, and those without histological liver damage. The highest specificity for alcoholism was achieved by gamma-ALAD; the best overall performance, with highest sensitivity and specificity was, however, gamma-GT. Although there was no correlation between the results of tests in individuals, 32/37 (87%) of alcoholics had at least one of the three tests abnormal compared with 8% of controls and 64% of non-alcoholic liver disease patients. The tests are therefore complementary and may form a battery of tests for problem drinking and its physical consequences.
一种因摄入酒精而暂时受到抑制的酶，即红细胞δ-氨基乙酰丙酸脱水酶（δ-ALAD），与门诊患者下午随机测定的血液乙醇含量及血浆γ-谷氨酰转移酶（γ-GT）进行了比较。研究对象包括37名慢性酒精中毒患者，其中14人患有严重肝病，22名非酒精性肝病患者以及24名健康对照者。所有检测方法在区分有组织学肝损伤和无组织学肝损伤的酗酒者方面表现不佳。γ-ALAD对酒精中毒的特异性最高；然而，综合表现最佳、灵敏度和特异性最高的是γ-GT。尽管个体检测结果之间无相关性，但37名酗酒者中有32/37（87%）至少一项检测结果异常，相比之下，对照组为8%，非酒精性肝病患者为64%。因此，这些检测方法具有互补性，可构成一组针对问题饮酒及其身体后果的检测项目。
