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基于风险的定价模型及其在患者获取新干细胞疗法方面可能发挥的作用。

Risk-based pricing models and the role they might play in patients' access to new stem cell therapies.

作者信息

Hoeyer Klaus, Borsch Anne Sofie, Jensen Kim Bak, Kirkeby Agnete, Steenholdt Casper, Wadmann Sarah

机构信息

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Regen Med. 2024 Dec;19(12):589-593. doi: 10.1080/17460751.2024.2441642. Epub 2024 Dec 18.

DOI:10.1080/17460751.2024.2441642
PMID:39691034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11703536/
Abstract

Stem cell research is currently undergoing a promising transformation from primarily basic research to increasing emphasis on translation and clinical trials. To reach patients, however, stem cell treatments need to be not only technically but also economically viable. In this commentry we present insights into emerging pricing models that may help ensure access to advanced and expensive treatments like stem cell therapies. Further, we present some reflections on the practical and ethical challenges that these models involve. We provide this information to allow the field of translational stem cell research to think ahead and to raise awareness of the outstanding social and ethical issues.

摘要

干细胞研究目前正经历着一场前景广阔的变革,从主要的基础研究逐渐转向更加注重转化研究和临床试验。然而,为了惠及患者,干细胞治疗不仅需要在技术上可行,还需要在经济上可行。在这篇评论中,我们深入探讨了新兴的定价模式,这些模式可能有助于确保人们能够获得诸如干细胞疗法等先进且昂贵的治疗。此外,我们还对这些模式所涉及的实际和伦理挑战进行了一些思考。我们提供这些信息,以便转化干细胞研究领域能够未雨绸缪,并提高对突出的社会和伦理问题的认识。

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本文引用的文献

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Reprogramming stem cells in regenerative medicine.再生医学中的干细胞重编程。
Smart Med. 2022 Dec 25;1(1):e20220005. doi: 10.1002/SMMD.20220005. eCollection 2022 Dec.
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Pricing and reimbursement mechanisms for advanced therapy medicinal products in 20 countries.20个国家的先进治疗药品定价与报销机制
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Lessons learnt, and still to learn, in first in human stem cell trials.在首例人体干细胞试验中吸取的经验教训和仍有待吸取的经验教训。
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