蜂胶与氯己定漱口水对口腔产亚硝酸盐细菌及血压调节的比较效果。
The comparative effect of propolis and chlorhexidine mouthwash on oral nitrite-producing bacteria and blood pressure regulation.
作者信息
Bescos R, du Toit L, Redondo-Rio A, Warburton P J, Nicholas T L, Kiernan M, Burton R A, Belfield L, Montagut G, Benavente A, Vevers W, Gabaldón T, Brookes Z, Casas-Agustench P
机构信息
School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK.
Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain.
出版信息
J Oral Microbiol. 2024 Dec 16;17(1):2439636. doi: 10.1080/20002297.2024.2439636. eCollection 2025.
BACKGROUND
Propolis mouthwash (PROP-M) has demonstrated antibacterial properties like those of chlorhexidine mouthwash (CHX-M). However, its impact on the abundance of oral nitrite-producing species (NPS) and nitrite-producing activity (NPA) remains unexplored.
METHODS
Forty-five healthy individuals were randomised into 2 groups to rinse their mouth twice a day for seven days with either CHX-M ( = 21) or PROP-M ( = 24). Metagenomic sequencing (16S rRNA) was performed on saliva samples collected before and after each treatment. Additionally, salivary biomarkers and blood pressure were measured.
RESULTS
CHX-M increased the relative abundance of NPS ( < 0.001) but significantly impaired the NPA ( < 0.001) compared to baseline and PROP-M. No significant differences in the relative abundance of NPS and NPA were observed in the PROP-M group. However, a significant increase of plasma nitrate (+7 µmol/L, = 0.047) and a decrease in systolic BP (-2 mmHg, = 0.022) was observed in this group compared to the baseline.
CONCLUSION
The results indicate that PROP-M had a smaller effect on the abundance of NPS and NPA compared to CHX-M. Additionally, PROP-M reduced blood pressure in healthy individuals, but this effect was not associated with changes in the oral microbiome.
背景
蜂胶漱口水（PROP-M）已显示出与氯己定漱口水（CHX-M）类似的抗菌特性。然而，其对口腔亚硝酸盐产生菌（NPS）丰度和亚硝酸盐产生活性（NPA）的影响仍未得到探索。
方法
45名健康个体被随机分为2组，分别使用CHX-M（n = 21）或PROP-M（n = 24）每天漱口两次，持续7天。对每次治疗前后采集的唾液样本进行宏基因组测序（16S rRNA）。此外，还测量了唾液生物标志物和血压。
结果
与基线和PROP-M相比，CHX-M增加了NPS的相对丰度（P < 0.001），但显著损害了NPA（P < 0.001）。在PROP-M组中，未观察到NPS和NPA相对丰度的显著差异。然而，与基线相比，该组血浆硝酸盐显著增加（+7 μmol/L，P = 0.047），收缩压降低（-2 mmHg，P = 0.022）。
结论
结果表明，与CHX-M相比，PROP-M对NPS丰度和NPA的影响较小。此外，PROP-M降低了健康个体的血压，但这种作用与口腔微生物群的变化无关。
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