蜂胶与洗必泰含漱液治疗牙龈炎的疗效比较：一项随机对照临床研究。
Comparative effectiveness of Propolis with chlorhexidine mouthwash on gingivitis - a randomized controlled clinical study.
机构信息
Division of Clinical Oral Health Sciences, School of Dentistry, IMU University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia.
Department of Oral Pathology Oral Medicine, Faculty of Dentistry, MAHSA University, Bandar Saujana Putra, Jenjarom, Selangor, 42610, Malaysia.
出版信息
BMC Complement Med Ther. 2024 Apr 6;24(1):154. doi: 10.1186/s12906-024-04456-8.
BACKGROUND
To assess and compare the effectiveness of propolis mouthwash with chlorhexidine mouthwash in the reduction of plaque and gingivitis.
METHODS
A single centre, latin-square cross-over, double masked, randomized controlled clinical trial was conducted on 45 chronic generalized gingivitis subjects who were chosen from the dental clinic of MAHSA University, Malaysia. A total of 45 subjects were randomly assigned into one of the three different groups (n = 15 each) using a computer-generated random allocation sequence: Group A Propolis mouthwash; Group B Chlorhexidine mouthwash; and Group C Placebo mouthwash. Supragingival plaque and gingival inflammation were assessed by full mouth Plaque index (PI) and gingival index (GI) at baseline and after 21 days. The study was divided into three phases, each phase lasted for 21 days separated by a washout period of 15 days in between them. Groups A, B and C were treated with 0.2% Propolis, Chlorhexidine, and Placebo mouthwash, respectively, in phase I. The study subjects were instructed to use the assigned mouthwash twice daily for 1 min for 21 days. On day 22, the subjects were recalled for measurement of PI and GI. After phase I, mouthwash was crossed over as dictated by the Latin square design in phase II and III.
RESULTS
At baseline, intergroup comparison revealed no statistically significant difference between Groups A, B and C (p > 0.05). On day 21, one-way ANOVA revealed statistically significant difference between the three groups for PI (p < 0.001) and GI (p < 0.001). Bonferroni post-hoc test showed statistically significant difference between Propolis and Chlorhexidine mouthwash (P < 0.001), with higher reduction in the mean plaque and gingival scores in propolis group compared to chlorhexidine and placebo groups.
CONCLUSIONS
Propolis mouthwash demonstrated significant improvement in gingival health and plaque reduction. Thus, it could be used as an effective herbal mouthwash alternative to chlorhexidine mouthwash.
TRIAL REGISTRATION
The trial was retrospectively registered on 25/07/2019 at clinicaltrials.gov and its identifier is NCT04032548.
背景
评估和比较蜂胶漱口水和洗必泰漱口水在减少菌斑和牙龈炎方面的效果。
方法
在马来西亚玛莎大学牙科诊所选择了 45 名慢性广泛性牙龈炎患者，进行了一项单中心、拉丁方交叉、双盲、随机对照临床试验。使用计算机生成的随机分配序列将 45 名受试者随机分为三组（每组 15 名）：A 组蜂胶漱口水；B 组洗必泰漱口水；C 组安慰剂漱口水。在基线和 21 天后，通过全口菌斑指数（PI）和牙龈指数（GI）评估龈上菌斑和牙龈炎症。研究分为三个阶段，每个阶段持续 21 天，中间间隔 15 天的洗脱期。在第一阶段，A、B 和 C 组分别用 0.2%蜂胶、洗必泰、安慰剂漱口液治疗。研究对象被指示在 21 天内每天使用分配的漱口水两次，每次 1 分钟。第 22 天，召回受试者测量 PI 和 GI。在第一阶段之后，根据拉丁方设计在第二阶段和第三阶段进行了漱口水交叉。
结果
在基线时，组间比较显示 A、B 和 C 组之间无统计学差异（p>0.05）。在第 21 天，单因素方差分析显示三组间 PI（p<0.001）和 GI（p<0.001）有统计学差异。Bonferroni 事后检验显示蜂胶和洗必泰漱口水之间有统计学差异（P<0.001），与洗必泰和安慰剂组相比，蜂胶组的平均菌斑和牙龈评分降低更明显。
结论
蜂胶漱口水在改善牙龈健康和减少菌斑方面显示出显著效果。因此，它可以作为洗必泰漱口水的有效替代草药漱口水。
试验注册
该试验于 2019 年 7 月 25 日在 clinicaltrials.gov 进行了回顾性注册，其标识符为 NCT04032548。
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