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大菱鲆中Th2免疫相关基因IL4/13A的鉴定与表达分析()。 （注：原文括号处内容缺失，翻译只能到此程度）

Identification and expression analysis of Th2 immune-related gene IL4/13A in turbot ().

作者信息

Huo Huanhuan, Liu Baoliang, Wang Zirui, Zhou Qiubai

机构信息

College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, China.

Key Laboratory of Sustainable Development of Marine Fisheries of Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China.

出版信息

Front Immunol. 2024 Dec 3;15:1500840. doi: 10.3389/fimmu.2024.1500840. eCollection 2024.

DOI:10.3389/fimmu.2024.1500840
PMID:39691705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11649633/
Abstract

Th2 immunity is a primary host defense against extracellular pathogens, and different IL4/13 paralogues are involved in this immune response in fish. Here, we identified IL4/13A for further Th2 immune response providing information in turbot. The results showed that the full length of the IL4/13A gene is 1,333 bp, containing a 432-bp open reading frame (ORF) that encoded 144 amino acids. Phylogenetic analysis recently showed that turbot IL4/13A has a relationship with . Moreover, syntenic analysis revealed similar neighboring genes associated with turbot IL4/13A, compared with other teleosts and mammals. In addition, IL4/13A was widely expressed in all examined tissues with the highest expression level in skin, followed by liver and gill. Finally, IL4/13A showed a general trend of upregulation in immune tissues following bacterial challenge. The significant quick induction of IL4/13A indicated its key roles to prevent pathogens. Characterizations of IL4/13A will probably contribute to understanding of Th2 immunity in fish.

摘要

Th2免疫是宿主抵御细胞外病原体的主要防御机制，不同的IL4/13旁系同源物参与鱼类的这种免疫反应。在此，我们鉴定出IL4/13A，以便为大菱鲆的Th2免疫反应提供更多信息。结果表明，IL4/13A基因全长1333 bp，包含一个432 bp的开放阅读框（ORF），编码144个氨基酸。系统发育分析最近表明，大菱鲆IL4/13A与……有关系。此外，与其他硬骨鱼和哺乳动物相比，共线性分析揭示了与大菱鲆IL4/13A相关的相似邻近基因。另外，IL4/13A在所有检测组织中广泛表达，在皮肤中的表达水平最高，其次是肝脏和鳃。最后，在细菌攻击后，IL4/13A在免疫组织中呈现普遍上调趋势。IL4/13A的显著快速诱导表明其在预防病原体方面的关键作用。IL4/13A的特性可能有助于理解鱼类的Th2免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/9eea9ae06867/fimmu-15-1500840-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/fbd7c96c9578/fimmu-15-1500840-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/b49f6006f2ca/fimmu-15-1500840-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/e871b02708cb/fimmu-15-1500840-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/8cbece2ec955/fimmu-15-1500840-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/1e1d2a540216/fimmu-15-1500840-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/9eea9ae06867/fimmu-15-1500840-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/fbd7c96c9578/fimmu-15-1500840-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/b49f6006f2ca/fimmu-15-1500840-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/e871b02708cb/fimmu-15-1500840-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/8cbece2ec955/fimmu-15-1500840-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/1e1d2a540216/fimmu-15-1500840-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ec/11649633/9eea9ae06867/fimmu-15-1500840-g006.jpg

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本文引用的文献

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