Zheng Shuting, Farmer Cristan, Taylor Julie Lounds, Adams Ryan, Olson Lindsay, Bishop Somer
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United States.
Neurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, Bethesda, MD, United States.
Front Psychiatry. 2024 Dec 3;15:1461704. doi: 10.3389/fpsyt.2024.1461704. eCollection 2024.
Autistic adults are at elevated risk for depression. However, longitudinal data on the trajectory of depressive symptoms and its associated factors in autistic adults are scarce.
A community sample of 315 autistic adults participated in a two-year longitudinal study from the beginning of (March 2020) to the recovery from the COVID-19 pandemic (March 2022). They provided five waves of data on self-reported depressive symptoms and sociodemographic and life circumstances information.
Multilevel model results showed that autistic adults reported large between-individual variability in self-reported depressive symptoms, and on average, they experienced an increase (i.e., worsening) in self-reported depressive symptoms over the two years of the study. Autistic adults with a depression history and lower annual household income reported higher levels of depressive symptoms. More importantly, autistic adults reported lower depressive symptoms when they were engaged in work or school, and those who had higher levels of depressive symptoms at the start of the study were more reactive to changes in work or school participation.
Findings from the current study have implications for potential venues of depression treatment in autistic adults around promoting employment/education, providing symptom monitoring, and addressing mental health disparities for those with lower incomes.
成年自闭症患者患抑郁症的风险较高。然而,关于成年自闭症患者抑郁症状轨迹及其相关因素的纵向数据却很匮乏。
一个由315名成年自闭症患者组成的社区样本参与了一项为期两年的纵向研究,从(2020年3月)开始至新冠疫情结束(2022年3月)。他们提供了五轮关于自我报告的抑郁症状以及社会人口统计学和生活状况信息的数据。
多层次模型结果显示,成年自闭症患者在自我报告的抑郁症状方面存在较大的个体间差异,并且在研究的两年中,他们自我报告的抑郁症状平均有所增加(即恶化)。有抑郁病史且家庭年收入较低的成年自闭症患者报告的抑郁症状水平较高。更重要的是,成年自闭症患者在工作或上学时报告的抑郁症状较低,并且在研究开始时抑郁症状水平较高的患者对工作或上学参与度的变化反应更大。
本研究结果对于成年自闭症患者抑郁症治疗的潜在途径具有启示意义,包括促进就业/教育、提供症状监测以及解决低收入者的心理健康差距问题。