Bezwoda W R, Derman D P, See N, Mansoor N
Oncology. 1985;42(1):7-12. doi: 10.1159/000225992.
Oestrogen receptor content, lactoferrin, hexokinase, and glucose-6-phosphate dehydrogenase levels were measured in cytosol from 25 primary breast cancers and 3 fibroadenomas. Both hexokinase and glucose-6-phosphate dehydrogenase activity were higher in malignant tissue as compared to benign breast lesions. Oestrogen receptor concentration and lactoferrin content failed to predict the development of metastatic disease, while glucose-6-phosphate dehydrogenase activity was significantly higher in cytosol from those tumours which subsequently metastasized compared to those which remained localized.
检测了25例原发性乳腺癌和3例纤维腺瘤细胞溶质中的雌激素受体含量、乳铁蛋白、己糖激酶和葡萄糖-6-磷酸脱氢酶水平。与良性乳腺病变相比，恶性组织中的己糖激酶和葡萄糖-6-磷酸脱氢酶活性均较高。雌激素受体浓度和乳铁蛋白含量无法预测转移性疾病的发生，而与那些仍局限于原位的肿瘤相比，随后发生转移的肿瘤细胞溶质中的葡萄糖-6-磷酸脱氢酶活性显著更高。
