Poulsen H S, Frederiksen P
Acta Pathol Microbiol Scand A. 1981 Jul;89(4):263-70. doi: 10.1111/j.1699-0463.1981.tb00220.x.
The correlation between glucose-6-phosphate dehydrogenase activity and different tumour characteristics was investigated in human breast cancer tissue. The enzyme activity was measured by a histochemical method and the oestrogen receptor content by a dextran-coated charcoal assay. The proliferative activity of the tumours correlated positively with the glucose-6-phosphate dehydrogenase activity. No correlation was found between enzyme activity and tumour type and menopausal status, age, TNM-class nor oestrogen receptor content. Based on this investigation it is concluded that the activity of glucose-6-phosphate dehydrogenase reflects the proliferative status of the tumour but not the hormone dependency of the tumour.
