Kloske Courtney M, Mahinrad Simin, Barnum Christopher J, Batista Andre F, Bradshaw Elizabeth M, Butts Brittany, Carrillo Maria C, Chakrabarty Paramita, Chen Xiaoying, Craft Suzanne, Da Mesquita Sandro, Dabin Luke C, Devanand Davangere, Duran-Laforet Violeta, Elyaman Wassim, Evans Elizabeth E, Fitzgerald-Bocarsly Patricia, Foley Kate E, Harms Ashley S, Heneka Michael T, Hong Soyon, Huang Yu-Wen A, Jackvony Stephanie, Lai Laijun, Guen Yann Le, Lemere Cynthia A, Liddelow Shane A, Martin-Peña Alfonso, Orr Anna G, Quintana Francisco J, Ramey Grace D, Rexach Jessica E, Rizzo Stacey J S, Sexton Claire, Tang Alice S, Torrellas Jose G, Tsai Andy P, van Olst Lynn, Walker Keenan A, Wharton Whitney, Tansey Malú Gámez, Wilcock Donna M
Alzheimer's Association, Chicago, Illinois, USA.
INmune Bio, Inc., Boca Raton, Florida, USA.
Alzheimers Dement. 2025 Jan;21(1):e14291. doi: 10.1002/alz.14291. Epub 2024 Dec 18.
The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders. HIGHLIGHTS: The immune system plays a central role in the pathogenesis of Alzheimer's disease. The immune system exerts numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The 2023 AAIC, Advancements: Immunity, encouraged discussions and collaborations on understanding the role of the immune system.
免疫系统在神经退行性疾病的发生和发展中起着关键作用。虽然脑内驻留免疫细胞介导的神经炎症以及外周免疫细胞（如T细胞）浸润入脑已被证明对阿尔茨海默病（AD）的病理过程有显著影响，但在AD及相关痴呆症（ADRD）背景下，脑内免疫反应的性质和程度仍不清楚。此外，外周免疫系统在驱动ADRD病理过程中的作用仍未完全阐明。2023年3月，阿尔茨海默病协会召开了阿尔茨海默病协会国际会议（AAIC）“进展：免疫”，以讨论免疫系统在ADRD中的作用。会议讨论了广泛的主题，如复制人类病理的动物模型、免疫相关生物标志物和临床试验，以及其他描述神经退行性变中免疫反应的领域的经验教训。本手稿介绍了会议的要点，并概述了未来关于免疫在神经退行性疾病中作用的研究途径。要点：免疫系统在阿尔茨海默病的发病机制中起核心作用。免疫系统在整个大脑中对β-淀粉样蛋白、tau蛋白及其他途径产生多种影响。2023年AAIC“进展：免疫”鼓励就理解免疫系统的作用展开讨论与合作。
