Peng Gaoyao, Li Jiangfa, Wang Xinchou
Department of Breast Surgery, Guilin Women's and Children's Hospital, No. 20, Fengbei Road, Guilin, China.
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Xiufen District, No. 15, Lequn Road, Guilin, 541001, Guangxi, China.
Discov Oncol. 2024 Dec 18;15(1):763. doi: 10.1007/s12672-024-01666-x.
We read with interest the study entitled "Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular "in Hepatology (Maestri E, Kedei N, Khatib S, et al. in Hepatology 79(4):768-79, 2024). This study utilized highly multiplexed CODEX imaging to comprehensively analyze the spatial interactions between tumor and immune cells in hepatocellular carcinoma (HCC), yielding several meaningful findings and innovatively proposing the concept of the spatial neighborhood of immune cell infiltration and confirming its association with patient prognosis. After reading the article carefully, we have some suggestions to point out.
我们饶有兴趣地阅读了发表于《肝脏病学》杂志（Maestri E、Kedei N、Khatib S等，《肝脏病学》79(4):768 - 79, 2024）上题为“肿瘤 - 免疫相互作用的空间邻近性预测肝细胞癌患者预后”的研究。该研究利用高度多重的CODEX成像技术全面分析了肝细胞癌（HCC）中肿瘤细胞与免疫细胞之间的空间相互作用，得出了一些有意义的发现，并创新性地提出了免疫细胞浸润空间邻域的概念，并证实了其与患者预后的关联。在仔细阅读该文章后，我们有一些建议要指出。
