Ding Qihang, Guo Aoxue, Zhang Shuai, Gu Chuanqi, Wang Xinyu, Li Xin, Gu Meijia, Kim Jong Seung
Department of Gynecology, Renmin Hospital of Wuhan University, Wuhan, 430072, China; Department of Chemistry, Korea University, Seoul, 02841, South Korea; Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Department of Gynecology, Renmin Hospital of Wuhan University, Wuhan, 430072, China.
Biomaterials. 2025 May;316:123012. doi: 10.1016/j.biomaterials.2024.123012. Epub 2024 Dec 15.
Gynecological inflammations have a significant impact on the daily lives of women. Meanwhile, cancers such as ovarian, cervical, and endometrial cancers pose severe threats to their physical and mental well-being. While current options such as conventional pharmacotherapy, surgical interventions, and recent advancements in immunotherapy and targeted therapy provide viable solutions, they possess limitations in effectively addressing the intricacies associated with gynecological diseases. These complexities include post-surgical complications, early cancer detection, and drug resistance. The management of these challenges, however, requires the implementation of innovative treatment modalities. Phototheranostics has emerged as a promising approach to effectively address these challenges. It not only treats inflammation and tumors efficiently but also aids in disease imaging and diagnosis. The distinguishing features of phototheranostics lie in their non-invasive nature, minimal risk of drug resistance, and precise targeting capabilities through the use of photosensitizers or photothermal agents. These distinctive features underscore its potential to revolutionize early diagnosis and treatment of gynecological conditions. This review aims to summarize the application of phototheranostics in managing gynecological inflammation and tumors while highlighting its significant potential for early disease detection and treatment.
妇科炎症对女性的日常生活有重大影响。同时，卵巢癌、宫颈癌和子宫内膜癌等癌症对她们的身心健康构成严重威胁。虽然目前的常规药物治疗、手术干预以及免疫治疗和靶向治疗的最新进展提供了可行的解决方案，但它们在有效解决与妇科疾病相关的复杂性方面存在局限性。这些复杂性包括术后并发症、癌症早期检测和耐药性。然而，应对这些挑战需要采用创新的治疗方式。光诊疗学已成为有效应对这些挑战的一种有前途的方法。它不仅能有效治疗炎症和肿瘤，还有助于疾病成像和诊断。光诊疗学的独特之处在于其非侵入性、耐药风险极小以及通过使用光敏剂或光热剂实现精确靶向的能力。这些独特特性突显了其变革妇科疾病早期诊断和治疗的潜力。本综述旨在总结光诊疗学在管理妇科炎症和肿瘤方面的应用，同时强调其在疾病早期检测和治疗方面的巨大潜力。
