潜伏性结核预防性治疗期间异烟肼所致急性肝衰竭：1例罕见尸检病例报告
Acute Liver Failure Caused by Isoniazid during Preventive Treatment for Latent Tuberculosis: A Rare Autopsy Case Report.
作者信息
Yamazaki Yuka, Tominaga Keiichi, Arisaka Takahiro, Tagaya Mayuko, Kojimahara Shunsuke, Ohnishi Toshihiko, Majima Yuichi, Yamamiya Akira, Iijima Makoto, Ikeda Naoya, Niho Seiji, Noda Shuhei, Ishida Kazuyuki, Irisawa Atsushi
机构信息
Department of Gastroenterology, Dokkyo Medical University School of Medicine, Japan.
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Japan.
出版信息
Intern Med. 2025 Jul 15;64(14):2160-2164. doi: 10.2169/internalmedicine.4720-24. Epub 2024 Dec 19.
Treating patients with latent tuberculosis infection (LTBI) to prevent the development of tuberculosis is a fundamental treatment strategy in daily practice. Isoniazid (INH) therapy for 6-12 months is recommended. However, INH can also cause hepatotoxicity. This report describes the autopsy case of a 65-year-old Japanese man diagnosed with LTBI who died of acute liver failure caused by INH.
治疗潜伏性结核感染（LTBI）患者以预防结核病的发生是日常临床实践中的一项基本治疗策略。推荐使用异烟肼（INH）治疗6至12个月。然而，异烟肼也可导致肝毒性。本报告描述了一名65岁日本男性的尸检病例，该患者被诊断为LTBI，死于异烟肼所致的急性肝衰竭。
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