Acute Liver Failure Caused by Isoniazid during Preventive Treatment for Latent Tuberculosis: A Rare Autopsy Case Report.

作者信息

Yamazaki Yuka, Tominaga Keiichi, Arisaka Takahiro, Tagaya Mayuko, Kojimahara Shunsuke, Ohnishi Toshihiko, Majima Yuichi, Yamamiya Akira, Iijima Makoto, Ikeda Naoya, Niho Seiji, Noda Shuhei, Ishida Kazuyuki, Irisawa Atsushi

机构信息

Department of Gastroenterology, Dokkyo Medical University School of Medicine, Japan.

Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Japan.

出版信息

Intern Med. 2025 Jul 15;64(14):2160-2164. doi: 10.2169/internalmedicine.4720-24. Epub 2024 Dec 19.

Treating patients with latent tuberculosis infection (LTBI) to prevent the development of tuberculosis is a fundamental treatment strategy in daily practice. Isoniazid (INH) therapy for 6-12 months is recommended. However, INH can also cause hepatotoxicity. This report describes the autopsy case of a 65-year-old Japanese man diagnosed with LTBI who died of acute liver failure caused by INH.