Hoffmann Angelika, Almiri William, Mordasini Pasquale, Bähler Alexandrine, Seiffge David J, Göldlin Martina B, Jäger Eugen, Muresan Ioan-Paul, Christ Lisa, Heldner Mirjam R, Wiest Roland, Radojewski Piotr
From the Institute for Diagnostic and Interventional Neuroradiology (A.H., W.A., P.M., A.B., R.W., P.R.), Inselspital, University of Bern, Bern, Switzerland.
Netzwerk Radiologie (P.M.), Kantonsspital St. Gallen, St. Gallen, Switzerland.
AJNR Am J Neuroradiol. 2025 Jun 3;46(6):1283-1286. doi: 10.3174/ajnr.A8627.
Imaging can help to diagnose CNS vasculitis. Yet so far, no imaging studies of CNS vasculitis at 7T are available. We share our experience of vessel wall imaging (VWI) at 7T in patients with suspected vasculitis. All included patients (=45) underwent a clinically approved 7T MRI comprising high-resolution arterial TOF angiography as well as high-resolution VWI with T1 sampling perfection with application-optimized contrast using different flip angle evolution (SPACE) and T1 SE acquired pre- and postcontrast. Twenty-three patients showed negative and 22 patients showed positive VWI at 7T. Ten of 22 7T VWI-positive cases were suggestive of vasculitis with 9 patients showing VWI of large- and medium-size vessels and 1 patient VWI of small vessels. Small-vessel vasculitis was only depicted with 7T VWI, but not 3T VWI. Our work demonstrates that diagnosing CNS vasculitis, especially small-vessel vasculitis, is feasible at 7T and highlights the potential of high-field VWI encouraging further studies in this field.
影像学有助于诊断中枢神经系统血管炎。然而，到目前为止，尚无7T场强下中枢神经系统血管炎的影像学研究。我们分享在7T场强下对疑似血管炎患者进行血管壁成像（VWI）的经验。所有纳入的患者（共45例）均接受了临床认可的7T磁共振成像检查，包括高分辨率动脉TOF血管造影以及使用不同翻转角演变的T1采样完美度与应用优化对比的高分辨率VWI（SPACE），并在注射对比剂前后采集T1 SE图像。23例患者7T场强下VWI为阴性，22例为阳性。22例7T场强VWI阳性病例中有10例提示血管炎，其中9例患者大、中血管有VWI表现，1例患者小血管有VWI表现。小血管血管炎仅在7T场强VWI中显示，3T场强VWI未显示。我们的研究表明，在7T场强下诊断中枢神经系统血管炎，尤其是小血管血管炎是可行的，并突出了高场强VWI的潜力，鼓励在该领域开展进一步研究。
