Tang Ruizhi, Liu Xi-Qiu
Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2024 Dec 4;15:1466017. doi: 10.3389/fphar.2024.1466017. eCollection 2024.
Breast cancer is a complex disease and its progression is related not only to tumor cells but also to its microenvironment, which can not be sufficiently reflected by the traditional monolayer cell culture manner. The novel human cancer models comprising tumor microenvironment (TME), such as tumor organoids and organs-on-a-chip, has been established in recent years to help elucidate the underlying mechanisms of tumorigenesis and promote the development of cancer therapies. In this review, we first discuss the current state of breast cancer and their treatment strategies, and elucidates the complex properties of TME of breast cancer . The culture models used in breast cancer research are then summarized with insights into recent development. Finally, we also conclude by discussing the current limitations and future directions of culture models in breast cancer research for providing a preclinical reference for the precise treatment of cancer patients.
乳腺癌是一种复杂的疾病，其进展不仅与肿瘤细胞有关，还与其微环境有关，而传统的单层细胞培养方式无法充分反映这种微环境。近年来，已建立了包括肿瘤微环境（TME）的新型人类癌症模型，如肿瘤类器官和芯片上的器官，以帮助阐明肿瘤发生的潜在机制并促进癌症治疗的发展。在本综述中，我们首先讨论乳腺癌的现状及其治疗策略，并阐明乳腺癌TME的复杂特性。然后总结了乳腺癌研究中使用的培养模型，并对其最新进展进行了深入分析。最后，我们还通过讨论乳腺癌研究中培养模型的当前局限性和未来方向来得出结论，以为癌症患者的精准治疗提供临床前参考。
