Wu Da-Wen, Yang Ze-Yi, Nie Yan, Ye He-Ya, Chen Liang, Liu Long-Qian, Yang Guo-Yuan
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Laboratory of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Int J Ophthalmol. 2024 Dec 18;17(12):2236-2242. doi: 10.18240/ijo.2024.12.11. eCollection 2024.
To evaluate the refraction difference value (RDV) variations in children and adolescents with different refractive errors and analyze its correlation with refractive development.
Participants aged 4-16y with different refractive statuses (hyperopia, emmetropia, myopia) underwent comprehensive eye examinations, including spherical equivalent (SE) refraction, axial length (AL), total RDV (TRDV), and RDVs at various eccentricities (0°-15°, 15°-30°, 30°-45°) and quadrants (inferior, superior, nasal, temporal). Statistical analysis involved one-way ANOVA for group comparisons and Pearson correlation for examining relationships between SE/AL and RDVs. Paired -tests compared quadrant-specific RDVs within groups.
Significant difference was found in TRDV (<0.001), RDV15°-30° (=0.033), RDV30°-45° (<0.001), RDV-inferior (RDV-I, <0.001) and RDV-temporal (RDV-T, <0.001) among hyperopia, emmetropia and myopia group. Pearson correlation analysis revealed a negative correlation of SE with TRDV (=0.001), RDV30°-45° (=0.004), RDV-I (=0.047), and RDV-T (<0.001). The differences between RDV-superior (RDV-S) and RDV-I were statistically significant in all groups (<0.001 for all) and between RDV-T and RDV-nasal (RDV-N) were statistically significant in hyperopia group (<0.001). Within the pre-myopic group, the analysis revealed a negative correlation of SE with RDV-I (=0.009). Pearson correlation analysis revealed a positive correlation of AL with TRDV (=0.036), RDV15°-30° (=0.004), RDV30°-45° (<0.001), RDV-S (=0.003), RDV-I (<0.001), RDV-T (<0.001), RDV-N (=0.022), while revealed a negative correlation of AL with RDV0-15° (=0.018).
Our study indicates TRDV, RDV30°-45°, RDV-I, RDV-T may relate to refractive development, and a negative correlation between SE and RDV-I in pre-myopic children.
评估不同屈光不正的儿童和青少年的屈光差值（RDV）变化，并分析其与屈光发育的相关性。
对年龄在4 - 16岁、具有不同屈光状态（远视、正视、近视）的参与者进行全面的眼部检查，包括等效球镜度（SE）验光、眼轴长度（AL）、总RDV（TRDV）以及不同偏心度（0° - 15°、15° - 30°、30° - 45°）和象限（下方、上方、鼻侧、颞侧）的RDV。统计分析包括用于组间比较的单因素方差分析以及用于检验SE/AL与RDV之间关系的Pearson相关性分析。配对t检验比较组内特定象限的RDV。
远视、正视和近视组之间在TRDV（<0.001）、RDV15° - 30°（=0.033）、RDV30° - 45°（<0.001）、下方RDV（RDV - I，<0.001）和颞侧RDV（RDV - T，<0.001）方面存在显著差异。Pearson相关性分析显示SE与TRDV（=0.001）、RDV30° - 45°（=0.004）、RDV - I（=0.047）和RDV - T（<0.001）呈负相关。所有组中上方RDV（RDV - S）与RDV - I之间的差异均具有统计学意义（均<0.001），远视组中RDV - T与鼻侧RDV（RDV - N）之间的差异具有统计学意义（<0.001）。在近视前期组中，分析显示SE与RDV - I呈负相关（=0.009）。Pearson相关性分析显示AL与TRDV（=0.036）、RDV15° - 30°（=0.004）、RDV30° - 45°（<0.001）、RDV - S（=0.003）、RDV - I（<0.001）、RDV - T（<0.001）、RDV - N（=0.022）呈正相关，而AL与RDV0 - 15°呈负相关（=0.018）。
我们的研究表明TRDV、RDV30° - 45°、RDV - I、RDV - T可能与屈光发育有关，且近视前期儿童的SE与RDV - I之间存在负相关。
