Li Tao, Jiang Bo, Zhou Xiaodong
Department of Ophthalmology, Fudan University Jinshan Hospital, 1508 Longhang Road, Shanghai, 201508, China.
Jinshan District Eye Disease Prevention and Treatment Center, Shanghai, China.
Sci Rep. 2025 Jul 1;15(1):21361. doi: 10.1038/s41598-025-04334-4.
The purpose of this study was to assess the retinal relative peripheral refraction (RPR) in children with low myopia and pre-myopia, and investigate the differences in RPR using multispectral refraction topography (MRT). Ninety-five children were enrolled in the Department of Ophthalmology, Jinshan Hospital affiliated to Fudan University. MRT could measure total RPR (TRPR) of the 53° range centered on macular fovea. TRPR divided into four quadrants: superior RPR (RPR-S), inferior RPR (RPR-I), temporal RPR (RPR-T) and nasal RPR (RPR-N). The MRT analysis report also showed RPR in the visual field of 15° (RPR-15), 30° (RPR-30) and 45° (RPR-45) centered on the macular fovea, respectively. RPR-(15-30), RPR-(30-45) and RPR-(15-45) were calculated. TRPR (R = - 0.264, P = 0.010), RPR-I (R = - 0.261, P = 0.011), RPR-T (R = - 0.240, P = 0.019), RPR-45 (R = - 0.211, P = 0.040), RPR-(30-45) (R = - 0.232, P = 0.023) and RPR-(15-45) (R = - 0.243, P = 0.018) were negatively correlated with spherical refraction. Spherical equivalent of low myopia group was significantly less than pre-myopia group (- 1.18 ± 0.57 D vs. 0.13 ± 0.31 D, P < 0.001) whereas axial length of low myopia group was significantly longer than pre-myopia group (24.14 ± 0.70 mm vs. 23.35 ± 0.60 mm, P < 0.001). TRPR of low myopia group and pre-myopia group was 0.52 ± 0.62 D and 0.32 ± 0.41 D, respectively, without sigficant difference (P = 0.075). All the RPRs were hyperopia in the children with low myopia and pre-myopia, except for RPR-T in pre-myopia group. RPR-I in low myopia group was significantly larger than that in pre-myopia group (0.42 ± 0.72 (95% CI 0.22, 0.62) D vs. 0.04 ± 0.67 (95% CI - 0.17, 0.25) D, P = 0.010). In conclusion, RPRs become more hyperopia with the changing trend from pre-myopia to myopia. Children with low myopia and pre-myopia have relative peripheral hyperopia. Furthermore, children with low myopia have larger relative peripheral hyperopia compared with pre-myopia.
本研究旨在评估低度近视和近视前期儿童的视网膜相对周边屈光（RPR），并使用多光谱屈光地形图（MRT）研究RPR的差异。95名儿童纳入复旦大学附属金山医院眼科。MRT可测量以黄斑中心凹为中心的53°范围的总RPR（TRPR）。TRPR分为四个象限：上RPR（RPR-S）、下RPR（RPR-I）、颞侧RPR（RPR-T）和鼻侧RPR（RPR-N）。MRT分析报告还分别显示了以黄斑中心凹为中心的15°（RPR-15）、30°（RPR-30）和45°（RPR-45）视野中的RPR。计算了RPR-(15-30)、RPR-(30-45)和RPR-(15-45)。TRPR（R = -0.264，P = 0.010）、RPR-I（R = -0.261，P = 0.011）、RPR-T（R = -0.240，P = 0.019）、RPR-45（R = -0.211，P = 0.040）、RPR-(30-45)（R = -0.232，P = 0.023）和RPR-(15-45)（R = -0.243，P = 0.018）与球镜屈光呈负相关。低度近视组的等效球镜显著低于近视前期组（-1.18±0.57 D vs. 0.13±0.31 D，P < 0.001），而低度近视组的眼轴长度显著长于近视前期组（24.14±0.70 mm vs. 23.35±0.60 mm，P < 0.001）。低度近视组和近视前期组的TRPR分别为0.52±0.62 D和0.32±0.41 D，无显著差异（P = 0.075）。除近视前期组的RPR-T外，低度近视和近视前期儿童的所有RPR均为远视。低度近视组的RPR-I显著大于近视前期组（0.42±0.72（95%CI 0.22，0.62）D vs. 0.04±0.67（95%CI -0.17，0.25）D，P = 0.010）。总之，随着从近视前期到近视的变化趋势，RPR变得更加远视。低度近视和近视前期儿童有相对周边远视。此外，与近视前期儿童相比，低度近视儿童有更大的相对周边远视。
