Saeed Ali Y, Rashad Brisik H, Ali Bakhtyar N, Sulaivany Ahmed H, Ibrahim Khalid S
Department of Biology, College of Science, University of Duhok, Duhok, IRQ.
Department of Biomedical Sciences, College of Medicine, University of Zakho, Zakho, IRQ.
Cureus. 2024 Nov 17;16(11):e73873. doi: 10.7759/cureus.73873. eCollection 2024 Nov.
() is a globally prevalent bacterium, infecting roughly half the global population, with higher prevalence rates in developing countries. This study aimed to investigate the prevalence of among symptomatic dyspeptic patients in Zakho City, Iraq, evaluate its association with various risk factors, as well as evaluate the effectiveness of treatment in curing this bacterium. Of a total of 150 dyspeptic patients, 50 who had received antibiotics were excluded, leaving 100 patients without antibiotics enrolled in this study. These participants, aged 11-67 years, visited the private Nawroz Laboratory in Zakho City, Kurdistan, Iraq, between June 2021 and October 2022. These patients were tested using the Helicoprobe 14C-Urea breath test and data on various factors, including age, gender, smoking, family size, drinking water source, education level, BMI, hemoglobin levels, and blood group, were collected through structured interviews. In this study, the prevalence of this bacterium was 50%, with no significant difference observed between males and females as well as BMI, smoking, source of drinking water, and blood groups while significant associations were found between infection and increasing age, low Hb levels, and educational level. Notably, 46.7% of patients failed to respond to standard triple therapy, possibly due to antibiotic resistance. The ineffectiveness of standard triple therapy for highlights the need for tailored treatments based on local antibiotic resistance patterns to improve prevention and treatment strategies with further investigation studies.
（）是一种全球流行的细菌，感染了全球约一半的人口，在发展中国家的流行率更高。本研究旨在调查伊拉克扎胡市有症状消化不良患者中该细菌的流行情况，评估其与各种风险因素的关联，并评估治疗该细菌的有效性。在总共150名消化不良患者中，排除了50名接受过抗生素治疗的患者，本研究纳入了100名未接受过抗生素治疗的患者。这些参与者年龄在11至67岁之间，于2021年6月至2022年10月期间前往伊拉克库尔德斯坦扎胡市的私立纳乌鲁兹实验室就诊。这些患者使用Helicoprobe 14C-尿素呼气试验进行检测，并通过结构化访谈收集了包括年龄、性别、吸烟、家庭规模、饮用水源、教育水平、体重指数、血红蛋白水平和血型等各种因素的数据。在本研究中，该细菌的流行率为50%，男性与女性之间以及体重指数、吸烟、饮用水源和血型之间未观察到显著差异，而感染与年龄增长、低血红蛋白水平和教育水平之间存在显著关联。值得注意的是，46.7%的患者对标准三联疗法无反应，可能是由于抗生素耐药性。标准三联疗法对（该细菌）无效凸显了需要根据当地抗生素耐药模式制定个性化治疗方案，以通过进一步的调查研究改进预防和治疗策略。
