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蝶骨-眶脑膜瘤:治疗方式、辅助治疗及复发风险的系统评价

Spheno-Orbital Meningiomas: A Systematic Review of Treatment Modalities, Adjuvant Therapies, and Recurrence Risk.

作者信息

Sulaiman Injam Ibrahim, Hassan Baker Ali, Shafeeq Azhin, Ismail Mustafa

机构信息

Department of Surgery, Hawler Medical University, College of Medicine, Erbil, IRQ.

Department of Neurosurgery, Hawler Teaching Hospital, Erbil, IRQ.

出版信息

Cureus. 2024 Nov 18;16(11):e73908. doi: 10.7759/cureus.73908. eCollection 2024 Nov.

DOI:10.7759/cureus.73908
PMID:39697949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11653974/
Abstract

Spheno-orbital meningiomas (SOMs) are rare tumors that involve the sphenoid wing and orbit, leading to symptoms such as proptosis and vision loss. Their proximity to critical neurovascular structures complicates surgical resection, making management challenging. A systematic review of 22 paper series involving 1042 patients was conducted using PubMed and Scopus. Studies focused on SOM diagnosis, surgical techniques, recurrence rates, and the role of adjuvant therapies were analyzed. Proptosis and visual impairment were the most common symptoms. Gross total resection (GTR) reduced recurrence, but subtotal resection (STR) often led to higher recurrence, particularly in optic canal involvement. Minimally invasive approaches showed the potential to reduce morbidity. Adjuvant radiotherapy was effective in controlling tumor growth post-STR. SOM management requires a balance between tumor control and functional preservation. While GTR minimizes recurrence, STR with adjuvant radiotherapy is a viable alternative in challenging cases. Minimally invasive techniques offer promise, but further long-term studies are needed.

摘要

蝶骨-眶脑膜瘤(SOMs)是一种罕见的肿瘤,累及蝶骨翼和眼眶,可导致眼球突出和视力丧失等症状。它们靠近关键的神经血管结构,使手术切除变得复杂,给治疗带来挑战。利用PubMed和Scopus对涉及1042例患者的22篇论文系列进行了系统评价。分析了聚焦于SOM诊断、手术技术、复发率及辅助治疗作用的研究。眼球突出和视力损害是最常见的症状。全切除(GTR)可降低复发率,但次全切除(STR)往往导致更高的复发率,尤其是在视神经管受累的情况下。微创方法显示出降低发病率的潜力。辅助放疗在STR后控制肿瘤生长方面有效。SOM的治疗需要在肿瘤控制和功能保留之间取得平衡。虽然GTR可将复发率降至最低,但在具有挑战性的病例中,STR联合辅助放疗是一种可行的替代方案。微创技术前景广阔,但还需要进一步的长期研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7924/11653974/e8d6c02ad31f/cureus-0016-00000073908-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7924/11653974/e8d6c02ad31f/cureus-0016-00000073908-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7924/11653974/e8d6c02ad31f/cureus-0016-00000073908-i01.jpg

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本文引用的文献

1
23-year review of spheno-orbital meningioma: clinical, radiological, and pathological insights from 100 cases.蝶眶脑膜瘤 23 年回顾:100 例临床、放射学和病理学见解。
BMC Ophthalmol. 2024 Sep 2;24(1):386. doi: 10.1186/s12886-024-03653-w.
2
Recurrences of Spheno-Orbital Meningiomas: Risk Factors and Management.蝶眶脑膜瘤复发:危险因素与处理。
World Neurosurg. 2022 May;161:e514-e522. doi: 10.1016/j.wneu.2022.02.048. Epub 2022 Feb 26.
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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.《PRISMA 2020声明:报告系统评价的更新指南》
Syst Rev. 2021 Mar 29;10(1):89. doi: 10.1186/s13643-021-01626-4.
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The Alberta standardized orbital technique in the management of spheno-orbital meningiomas.
Eur J Ophthalmol. 2021 Sep;31(5):2686-2691. doi: 10.1177/1120672120960332. Epub 2020 Oct 2.
5
Visual outcomes endorse surgery of patients with spheno-orbital meningioma with minimal visual impairment or hyperostosis.视觉结果支持对有最小视力损害或骨肥厚的蝶眶脑膜瘤患者进行手术治疗。
Acta Neurochir (Wien). 2021 Jan;163(1):73-82. doi: 10.1007/s00701-020-04554-9. Epub 2020 Sep 4.
6
Spheno-Orbital Meningiomas: Optimizing Visual Outcome.蝶骨-眶脑膜瘤:优化视觉预后
J Neurosci Rural Pract. 2020 Jul;11(3):385-394. doi: 10.1055/s-0040-1709270. Epub 2020 May 11.
7
Surgery as a safe and effective treatment option for spheno-orbital meningioma: a systematic review and meta-analysis of surgical techniques and outcomes.手术作为治疗蝶眶脑膜瘤的安全有效的治疗选择:手术技术和结果的系统评价和荟萃分析。
Acta Ophthalmol. 2021 Feb;99(1):26-36. doi: 10.1111/aos.14517. Epub 2020 Jun 29.
8
Optimal indications and limitations of endoscopic transorbital superior eyelid surgery for spheno-orbital meningiomas.内镜经眶上眼睑入路手术治疗蝶眶脑膜瘤的最佳适应证和局限性。
J Neurosurg. 2020 Jun 5;134(5):1472-1479. doi: 10.3171/2020.3.JNS20297. Print 2021 May 1.
9
Combined neurosurgical and orbital intervention for spheno-orbital meningiomas - the Manchester experience.联合神经外科和眼眶介入治疗蝶眶脑膜瘤-曼彻斯特经验。
Orbit. 2020 Aug;39(4):251-257. doi: 10.1080/01676830.2019.1673782. Epub 2019 Oct 28.
10
A single centre's experience of managing spheno-orbital meningiomas: lessons for recurrent tumour surgery.单中心处理蝶眶脑膜瘤的经验:复发性肿瘤手术的教训。
Acta Neurochir (Wien). 2019 Aug;161(8):1657-1667. doi: 10.1007/s00701-019-03977-3. Epub 2019 Jun 26.