Liu Bei, Wang Lin, He Yufeng
Department of Medical Technology, Xi'an Medical University, Xi'an, Shaanxi, China.
Department of Clinical laboratory, Xi'an Medical University Second Affiliated Hospital, Xi'an, Shaanxi, China.
Int J Low Extrem Wounds. 2024 Dec 19:15347346241309180. doi: 10.1177/15347346241309180.
Diabetic Foot Ulcer (DFU) is a common and challenging complication of diabetes mellitus, associated with high recurrence, hospitalization, disability, and mortality rates. The Systemic Immune Inflammatory Index (SIRI) based on complete blood counts has been shown to correlate with several diseases but has not been widely studied in DFU.This study aimed to explore the relationship between SIRI and the presence of DFU in individuals with diabetes using data from the National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis was conducted on 1246 individuals with diabetes from NHANES cycles 1999-2000, 2001-2002, and 2003-2004. DFUs were identified through patient self-reported data. Multivariate logistic regression models assessed the association between SIRI and DFU, adjusting for potential confounders. Subgroup and interaction analyses were also performed. A total of 117 patients were identified as having DFU. Elevated SIRI levels were significantly associated with DFU presence. In fully adjusted models, a 1-unit increase in SIRI was associated with 24.0% higher odds of DFU prevalence (OR = 1.24; 95% CI: 1.07, 1.43) Subgroup analyses revealed consistent associations across different groups of age, gender, body mass index (BMI), HbA1c, blood glucose, and hemoglobin levels. The findings indicate a positive correlation between SIRI and DFUpresence. Further research is warranted to elucidate the mechanistic links and explore the clinical utility of SIRI in DFU management.
糖尿病足溃疡（DFU）是糖尿病常见且具有挑战性的并发症，与高复发率、住院率、致残率和死亡率相关。基于全血细胞计数的全身免疫炎症指数（SIRI）已被证明与多种疾病相关，但在DFU方面尚未得到广泛研究。本研究旨在利用美国国家健康与营养检查调查（NHANES）的数据，探讨SIRI与糖尿病患者DFU发生之间的关系。对NHANES 1999 - 2000年、2001 - 2002年和2003 - 2004年周期的1246例糖尿病患者进行了横断面分析。通过患者自我报告数据确定DFU。多变量逻辑回归模型评估了SIRI与DFU之间的关联，并对潜在混杂因素进行了调整。还进行了亚组分析和交互作用分析。共确定117例患者患有DFU。SIRI水平升高与DFU的存在显著相关。在完全调整模型中，SIRI每增加1个单位，DFU患病率的比值比高24.0%（OR = 1.24；95%CI：1.07，1.43）。亚组分析显示，在不同年龄、性别、体重指数（BMI）、糖化血红蛋白（HbA1c）、血糖和血红蛋白水平组中，关联一致。研究结果表明SIRI与DFU的存在呈正相关。有必要进一步研究以阐明其机制联系，并探索SIRI在DFU管理中的临床应用。
