Matin Abdul, Siddiqui Ruqaiyyah, Jayasekera Samantha, Khan Naveed Ahmed
School of Biological and Chemical Sciences, Birkbeck, University of London, London WC1E 7HX, England.
Clin Microbiol Rev. 2008 Jul;21(3):435-48. doi: 10.1128/CMR.00056-07.
Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98%. This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures.
曼氏巴通体是一种新出现的原生动物寄生虫，是一种累及中枢神经系统的肉芽肿性阿米巴脑炎病原体，病死率超过98%。本综述介绍了我们目前对曼氏巴通体感染、其发病机制和病理生理学、与该疾病相关的分子机制，以及曼氏巴通体的毒力特征的理解，这些毒力特征可能是治疗干预和/或预防措施开发的潜在靶点。
