苯磺酸瑞马唑仑与环泊酚用于老年患者无痛胃肠镜检查的有效性和安全性
Efficacy and safety of remimazolam besylate and ciprofol in painless gastrointestinal endoscopy in the elderly.
作者信息
Zhu Ziwei
机构信息
The Fourth Affiliated Hospital of Soochow University - Department of Anesthesiology - Suzhou, Jiangsu - China.
出版信息
Acta Cir Bras. 2024 Dec 16;39:e399324. doi: 10.1590/acb399324. eCollection 2024.
PURPOSE
This study aimed to ascertain the efficacy and safety of remimazolam besylate and ciprofol in elderly patients undergoing painless gastrointestinal endoscopy.
METHODS
Patients in the control group (n = 31) were anesthetized with ciprofol, and those in the observation group (n = 31) were anesthetized with remimazolam besylate. The anesthetic effect, analgesic effect, hemodynamics, cognitive function, and adverse reactions between the two groups were compared.
RESULTS
The observation group had shorter anesthesia onset time, recovery time, as well as anesthesia recovery room stay time and a higher effective rate of analgesia. At T1, T2, and T3, the mean arterial pressure and heart rate of the observation group were higher versus the control group; at T1 and T2, SpO2 in the observation group was higher versus the control group. The simple mental state scale score of the observation group was higher than that of the control group (all p 0.05). The total incidence of adverse reactions exhibited no difference between the two groups (p> 0.05).
CONCLUSION
Versus ciprofol, remimazolam besylate has better anesthetic and analgesic effects, more stable hemodynamics, less impact on patients' cognitive function, and good safety in elderly patients undergoing painless gastrointestinal endoscopy.
目的
本研究旨在确定苯磺酸瑞马唑仑和环泊酚在老年无痛胃肠镜检查患者中的有效性和安全性。
方法
对照组（n = 31）患者采用环泊酚麻醉，观察组（n = 31）患者采用苯磺酸瑞马唑仑麻醉。比较两组之间的麻醉效果、镇痛效果、血流动力学、认知功能及不良反应。
结果
观察组的麻醉起效时间、苏醒时间以及在麻醉恢复室停留时间均较短，镇痛有效率较高。在T1、T2和T3时，观察组的平均动脉压和心率高于对照组；在T1和T2时，观察组的SpO2高于对照组。观察组的简易精神状态量表评分高于对照组（均p<0.05）。两组不良反应总发生率差异无统计学意义（p>0.05）。
结论
与环泊酚相比，苯磺酸瑞马唑仑在老年无痛胃肠镜检查患者中具有更好的麻醉和镇痛效果、更稳定的血流动力学、对患者认知功能影响较小且安全性良好。
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