Dutra Valéria de Freitas, Andrade Heitor Duarte de, Nunes Viviane Regina Hernandez, Elia Gabriella Mafra, Torres Juliane Roberta Dias, Bub Carolina Bonet, Yokoyama Ana Paula Hitomi, Kutner José Mauro
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2024 Dec 16;22:eAO0563. doi: 10.31744/einstein_journal/2024AO0563. eCollection 2024.
This study compared the outcomes of two cohorts of patients with coronavirus disease 2019 (COVID-19) who received COVID-19 convalescent plasma transfusions between 2020 and 2021.
This retrospective study was conducted at a tertiary hospital in São Paulo, Brazil. We included a retrospective cohort of patients who received convalescent compassionate plasma, and another group of patients from a previous clinical study. We collected clinical and laboratory data on the day of and 5 days after transfusion. Patients with hematological or immunological conditions were excluded. Statistical significance was set at p<0.05.
COVID-19 convalescent plasma did not affect the outcomes of patients with severe COVID-19 when comparing the two cohorts transfused with different volumes and titers of neutralizing antibodies. Despite improvements in some laboratory parameters, no effect on clinical outcomes was observed. Dialysis negatively affected the length of intensive care unit stay, hospitalization, and mechanical ventilation use. Each higher point on the day 0 World Health Organization scale reduced the probability of hospital and intensive care unit discharge and the risk of mechanical ventilation discontinuation.
Dialysis and the assessed clinical severity represented by the World Health Organization scale on day 0 influenced the outcomes, whereas COVID-19 convalescent plasma transfusion did not.
本研究比较了2020年至2021年间接受新型冠状病毒肺炎（COVID-19）康复期血浆输注的两组COVID-19患者的治疗结果。
这项回顾性研究在巴西圣保罗的一家三级医院进行。我们纳入了一组接受康复期同情性血浆输注的回顾性队列患者，以及另一组来自先前临床研究的患者。我们收集了输血当天和输血后5天的临床和实验室数据。排除患有血液学或免疫学疾病的患者。设定统计学显著性为p<0.05。
在比较输注不同体积和中和抗体滴度的两组患者时，COVID-19康复期血浆并未影响重症COVID-19患者的治疗结果。尽管一些实验室参数有所改善，但未观察到对临床结果的影响。透析对重症监护病房住院时间、住院时间和机械通气使用有负面影响。世界卫生组织0天量表上每高一个点都会降低出院和重症监护病房出院的概率以及机械通气停用的风险。
透析和世界卫生组织0天量表所评估的临床严重程度影响了治疗结果，而COVID-19康复期血浆输注则没有。
