Lamm Thomas Tandrup, Von Schrottenberg Victoria, Rauch Anneline, Bach Bo, Pedersen Heidi Frølund, Rask Mette Trøllund, Ørnbøl Eva, Wellnitz Kaare Bro, Frostholm Lisbeth
Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Aarhus, Denmark.
Institute of General Practice and Health Services Research, TUM School of Medicine and Health, Technical University of Munich, Orleansstraße 47, 81667 Munich, Germany.
Clin Psychol Rev. 2025 Feb;115:102529. doi: 10.1016/j.cpr.2024.102529. Epub 2024 Dec 12.
Functional Somatic Disorders (FSD) is an umbrella term for various conditions characterized by persistent and troublesome physical symptoms, that are not better explained by other psychiatric or somatic conditions. Personality traits may play a crucial role in FSD, but the link is not fully understood. This study presents a systematic review and meta-analysis examines the relationship between the Five-Factor Model (FFM) of personality traits and FSD.
The review was based on the PRISMA statement, and drew data from systematic searches in PsycInfo, PubMed, and Embase. To be eligible for inclusion, studies had to include eligible FSD groups and control groups and to assess FFM traits. Data were analyzed using random effects models. Sub-group and sensitivity analyses as well as meta-regression were used to explore the heterogeneity and robustness of findings.
In total 6841 records were screened and 52 included. FSD cases scored higher on neuroticism (k = 46, Hedge's g = 0.72, [95 % CI, 0.61: 0.83]) and lower on extraversion (k = 31, g = -0.41, [-0.55:-0.28]) and agreeableness (k = 15, g = -0.22, [-0.36:-0.09]) than healthy/unspecified controls. FSD cases scored higher on neuroticism (k = 9, g = 0.26 [0.08:0.44]) and agreeableness (k = 4, g = 0.43 [0.28:0.59]) than somatic controls, but did not differ on extraversion (k = 6, g = -0.17 [-0.45:0.11]). No significant differences were found for conscientiousness and openness. For psychiatric controls, meta-analysis was only possible for neuroticism (k = 3,= -0.61, [-1.98:0.77]). Findings displayed significant heterogeneity but no publication bias.
This review reveals significant associations between FFM traits and FSD, providing insight into the etiology, classification, and management of FSD.
功能性躯体障碍（FSD）是一个统称，用于描述各种以持续且令人困扰的躯体症状为特征的疾病，而其他精神或躯体疾病无法更好地解释这些症状。人格特质可能在FSD中起关键作用，但这种联系尚未完全明确。本研究进行了一项系统综述和荟萃分析，以探讨人格特质的五因素模型（FFM）与FSD之间的关系。
本综述基于PRISMA声明，数据来源于对PsycInfo、PubMed和Embase的系统检索。符合纳入标准的研究必须包括符合条件的FSD组和对照组，并评估FFM特质。使用随机效应模型对数据进行分析。采用亚组分析、敏感性分析以及荟萃回归来探讨研究结果的异质性和稳健性。
共筛选了6841条记录，纳入52项研究。与健康/未明确说明的对照组相比，FSD患者在神经质方面得分更高（k = 46，Hedge's g = 0.72，[95%置信区间，0.61:0.83]），在外向性方面得分更低（k = 31，g = -0.41，[-0.55:-0.28]），在宜人性方面得分更低（k = 15，g = -0.22，[-0.36:-0.09]）。与躯体疾病对照组相比，FSD患者在神经质方面得分更高（k = 9，g = 0.26 [0.08:0.44]），在宜人性方面得分更高（k = 4，g = 0.43 [0.28:0.59]），但在外向性方面无差异（k = 6，g = -0.17 [-0.45:0.11]）。在尽责性和开放性方面未发现显著差异。对于精神疾病对照组，仅能对神经质进行荟萃分析（k = 3，g = -0.61，[-1.98:0.77]）。研究结果显示出显著的异质性，但无发表偏倚。
本综述揭示了FFM特质与FSD之间存在显著关联，为FSD的病因、分类和管理提供了见解。
