Vegesana Kasi, Thomas Paul G
Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cell Syst. 2024 Dec 18;15(12):1156-1167. doi: 10.1016/j.cels.2024.11.009.
In recent years, the advances in high-throughput and deep sequencing have generated a diverse amount of adaptive immune repertoire data. This surge in data has seen a proportional increase in computational methods aimed to characterize T cell receptor (TCR) repertoires. In this perspective, we will provide a brief commentary on the various domains of TCR repertoire analysis, their respective computational methods, and the ongoing challenges. Given the breadth of methods and applications of TCR analysis, we will focus our perspective on sequence-based computational methods.
近年来，高通量和深度测序技术的进步产生了大量多样化的适应性免疫组库数据。随着数据量的激增，旨在表征T细胞受体（TCR）组库的计算方法也相应增加。从这个角度出发，我们将简要评论TCR组库分析的各个领域、它们各自的计算方法以及当前面临的挑战。鉴于TCR分析方法和应用的广度，我们将把重点放在基于序列的计算方法上。
