Golshany Hazem, Helmy Shahinaz Ahmed, Morsy Nashwa Fathy Sayed, Kamal Aya, Yu Qun, Fan Liuping
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
Food Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt.
Int J Food Sci Nutr. 2025 Mar;76(2):95-121. doi: 10.1080/09637486.2024.2437472. Epub 2024 Dec 19.
This comprehensive review examines the impact of dietary patterns on gut microbiome composition and diversity from infancy to old age, linking these changes to age-related health outcomes. It investigates how the gut microbiome develops and changes across life stages, focusing on the influence of dietary factors. The review explores how early-life feeding practices, including breastfeeding and formula feeding, shape the infant gut microbiota and have lasting effects. In elderly individuals, alterations in the gut microbiome are associated with increased susceptibility to infections, chronic inflammation, metabolic disorders and cognitive decline. The critical role of diet in modulating the gut microbiome throughout life is emphasised, particularly the potential benefits of probiotics and fortified foods in promoting healthy ageing. By elucidating the mechanisms connecting food systems to gut health, this review provides insights into interventions that could enhance gut microbiome resilience and improve health outcomes across the lifespan.
这篇全面综述探讨了从婴儿期到老年期饮食模式对肠道微生物群组成和多样性的影响，并将这些变化与年龄相关的健康结果联系起来。它研究了肠道微生物群在生命各阶段的发育和变化情况，重点关注饮食因素的影响。该综述探讨了早期喂养方式，包括母乳喂养和配方奶喂养，如何塑造婴儿肠道微生物群并产生持久影响。在老年人中，肠道微生物群的改变与感染易感性增加、慢性炎症、代谢紊乱和认知衰退有关。强调了饮食在一生中调节肠道微生物群的关键作用，特别是益生菌和强化食品在促进健康老龄化方面的潜在益处。通过阐明将食物系统与肠道健康联系起来的机制，本综述为可增强肠道微生物群恢复力并改善整个生命周期健康结果的干预措施提供了见解。
