Sedik Sarah, Egger Matthias, Hoenigl Martin
Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, ECMM Excellence Center, Auenbruggerplatz 15, Graz 8036, Austria; Translational Mycology, Medical University of Graz, Graz, Austria. Electronic address: https://twitter.com/SarahSedik.
Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, ECMM Excellence Center, Auenbruggerplatz 15, Graz 8036, Austria; Translational Mycology, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address: https://twitter.com/MatthiasEgger11.
Infect Dis Clin North Am. 2025 Mar;39(1):1-22. doi: 10.1016/j.idc.2024.11.002. Epub 2024 Dec 18.
This review explores how climate change influences fungal disease dynamics, focusing on emergence of new fungal pathogens, increased antifungal resistance, expanding geographic ranges of fungal pathogens, and heightened host susceptibility. Rising temperatures and altered precipitation patterns enhance fungal growth and resistance mechanisms, complicating treatment efforts. Climate-driven geographic shifts are expanding the range of diseases like Valley fever, histoplasmosis, and blastomycosis. Additionally, natural disasters exacerbated by climate change increase exposure to fungal pathogens through environmental disruptions and trauma. Many of those impacts affect primarily those already disadvantaged by social determinants of health putting them at increased risk for fungal diseases.
本综述探讨了气候变化如何影响真菌病动态,重点关注新真菌病原体的出现、抗真菌耐药性增加、真菌病原体地理范围扩大以及宿主易感性增强。气温上升和降水模式改变会增强真菌生长和耐药机制,使治疗工作复杂化。气候驱动的地理变化正在扩大如谷热、组织胞浆菌病和芽生菌病等疾病的范围。此外,气候变化加剧的自然灾害通过环境破坏和创伤增加了接触真菌病原体的机会。这些影响中的许多主要影响那些已经因健康的社会决定因素而处于不利地位的人群,使他们患真菌病的风险增加。