Joan and Sanford I. Weill Department of Medicine, The Jill Roberts Institute for Research in Inflammatory Bowel Disease, and Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
MRC Centre for Medical Mycology at the University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK.
Cell. 2024 Sep 19;187(19):5121-5127. doi: 10.1016/j.cell.2024.08.016.
Fungi play critical roles in the homeostasis of ecosystems globally and have emerged as significant causes of an expanding repertoire of devastating diseases in plants, animals, and humans. In this Commentary, we highlight the importance of fungal pathogens and argue for concerted research efforts to enhance understanding of fungal virulence, antifungal immunity, novel drug targets, antifungal resistance, and the mycobiota to improve human health.
真菌在全球生态系统的动态平衡中发挥着关键作用，并且已经成为植物、动物和人类中不断扩大的毁灭性疾病的重要原因。在这篇评论中，我们强调了真菌病原体的重要性，并呼吁开展协同研究工作，以增强对真菌毒力、抗真菌免疫、新的药物靶点、抗真菌耐药性和真菌生物群的理解，从而改善人类健康。
