• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

偏振敏感光学相干断层扫描中利用校准去极化指数进行视网膜黑色素检测。

retinal melanin detection with the calibrated depolarization index in polarization-sensitive optical coherence tomography.

作者信息

Ke Mengyuan, Jiang Liqin, Barathi Veluchamy A, Cheong Jocelyn, Chua Jacqueline, Schmetterer Leopold, Leitgeb Rainer A, Liu Xinyu

机构信息

Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, Austria.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

出版信息

J Biomed Opt. 2024 Dec;29(12):126001. doi: 10.1117/1.JBO.29.12.126001. Epub 2024 Dec 19.

DOI:10.1117/1.JBO.29.12.126001
PMID:39703200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11657874/
Abstract

SIGNIFICANCE

A data-based calibration method with enhanced depolarization contrast in polarization-sensitive optical coherence tomography (PS-OCT) was developed and demonstrated effective for detecting melanin content in the eye.

AIM

We aim to mitigate the dependence between the measured depolarization metric and the intensity signal-to-noise ratio (SNR) for improved visualization of depolarizing tissues, especially in low SNR regions, and to demonstrate the enhanced depolarization contrast to evaluate melanin presence.

APPROACH

A function for calibrating the depolarization metric was experimentally derived from the young albino guinea pig, assuming depolarization free in the retina. A longitudinal study of guinea pigs (9 weeks) was conducted to assess the accumulation of melanin during early eye growth. Furthermore, the melanin content of the sub-macular choroid was compared in eyes with light and dark irides involving 14 human subjects in early middle adulthood.

RESULTS

We observed an increase in the improved depolarization contrast, which indicates potential melanin accumulation in the early eye development with age in the pigmented guinea pig eyes. We found a significant difference in melanin content between human eyes with light and dark colors.

CONCLUSIONS

Our proposed calibration method enhanced the visualization of depolarizing structures in PS-OCT, which can be generalized to all kinds of polarization-sensitive imaging and can potentially monitor melanin in healthy and pathological eyes.

摘要

意义

开发了一种基于数据的校准方法，用于提高偏振敏感光学相干断层扫描（PS-OCT）中的去极化对比度，并证明其在检测眼睛中的黑色素含量方面有效。

目的

我们旨在减轻测量的去极化指标与强度信噪比（SNR）之间的依赖性，以改善去极化组织的可视化，特别是在低信噪比区域，并展示增强的去极化对比度以评估黑色素的存在。

方法

假设视网膜中无去极化，通过对幼年白化豚鼠进行实验，得出了一种用于校准去极化指标的函数。对豚鼠进行了为期9周的纵向研究，以评估早期眼睛生长过程中黑色素的积累情况。此外，比较了14名中青年受试者中浅色和深色虹膜眼睛的黄斑下脉络膜黑色素含量。

结果

我们观察到改善后的去极化对比度有所增加，这表明在有色豚鼠眼睛中，随着年龄增长，早期眼睛发育中可能存在黑色素积累。我们发现浅色和深色人眼的黑色素含量存在显著差异。

结论

我们提出的校准方法增强了PS-OCT中去极化结构的可视化，可推广到各种偏振敏感成像，并有可能监测健康和患病眼睛中的黑色素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/63c775f4bad7/JBO-029-126001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/22008a5e4c79/JBO-029-126001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/0dacf399170e/JBO-029-126001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/18e8bc5aecde/JBO-029-126001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/15d8b673f3d9/JBO-029-126001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/5a91d54c8893/JBO-029-126001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/63c775f4bad7/JBO-029-126001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/22008a5e4c79/JBO-029-126001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/0dacf399170e/JBO-029-126001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/18e8bc5aecde/JBO-029-126001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/15d8b673f3d9/JBO-029-126001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/5a91d54c8893/JBO-029-126001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e399/11657874/63c775f4bad7/JBO-029-126001-g006.jpg

相似文献

1
retinal melanin detection with the calibrated depolarization index in polarization-sensitive optical coherence tomography.偏振敏感光学相干断层扫描中利用校准去极化指数进行视网膜黑色素检测。
J Biomed Opt. 2024 Dec;29(12):126001. doi: 10.1117/1.JBO.29.12.126001. Epub 2024 Dec 19.
2
Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.光学相干断层扫描（OCT）用于检测糖尿病视网膜病变患者的黄斑水肿。
Cochrane Database Syst Rev. 2015 Jan 7;1(1):CD008081. doi: 10.1002/14651858.CD008081.pub3.
3
Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.光学相干断层扫描（OCT）用于检测糖尿病视网膜病变患者的黄斑水肿。
Cochrane Database Syst Rev. 2011 Jul 6(7):CD008081. doi: 10.1002/14651858.CD008081.pub2.
4
Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography.使用合成多对比度偏振敏感光学相干断层扫描评估浆液性色素上皮脱离中的视网膜色素上皮变化。
Sci Rep. 2025 Jul 7;15(1):24304. doi: 10.1038/s41598-025-09302-6.
5
Ganglion Cell Layer Thickness as a Biomarker for Amyotrophic Lateral Sclerosis Functional Outcome: An OCT study.神经节细胞层厚度作为肌萎缩侧索硬化症功能预后的生物标志物：一项光学相干断层扫描研究。
Rom J Ophthalmol. 2025 Apr-Jun;69(2):200-207. doi: 10.22336/rjo.2025.32.
6
Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.多发性硬化症中的视网膜层分割：系统评价和荟萃分析。
Lancet Neurol. 2017 Oct;16(10):797-812. doi: 10.1016/S1474-4422(17)30278-8. Epub 2017 Sep 12.
7
Blue-light filtering intraocular lenses (IOLs) for protecting macular health.用于保护黄斑健康的蓝光滤过型人工晶状体
Cochrane Database Syst Rev. 2018 May 22;5(5):CD011977. doi: 10.1002/14651858.CD011977.pub2.
8
Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating birefringence-related image artifacts.利用伪去偏振参考光的偏振不敏感光相干断层扫描技术，以减轻双折射相关的图像伪影。
J Biomed Opt. 2024 Nov;29(11):116001. doi: 10.1117/1.JBO.29.11.116001. Epub 2024 Nov 4.
9
Artificial intelligence for diagnosing exudative age-related macular degeneration.人工智能在渗出性年龄相关性黄斑变性诊断中的应用。
Cochrane Database Syst Rev. 2024 Oct 17;10(10):CD015522. doi: 10.1002/14651858.CD015522.pub2.
10
Macular Optical Coherence Tomography Findings in Patients With Syphilitic Optic Neuropathy-A Case Series and Systematic Review.梅毒性视神经病变患者的黄斑光学相干断层扫描结果——病例系列与系统评价
J Neuroophthalmol. 2025 Jun 1;45(2):137-144. doi: 10.1097/WNO.0000000000002188. Epub 2024 Sep 10.

本文引用的文献

1
RPE melanin and its influence on the progression of AMD.色素上皮黑色素及其对 AMD 进展的影响。
Ageing Res Rev. 2024 Aug;99:102358. doi: 10.1016/j.arr.2024.102358. Epub 2024 Jun 1.
2
Retinal Nerve Fiber Layer Damage Assessment in Glaucomatous Eyes Using Retinal Retardance Measured by Polarization-Sensitive Optical Coherence Tomography.用偏振光相干断层扫描测量视网膜迟滞评估青光眼患者的视网膜神经纤维层损伤。
Transl Vis Sci Technol. 2024 May 1;13(5):9. doi: 10.1167/tvst.13.5.9.
3
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression.
三重输入偏振敏感成像测量的后巩膜双折射作为近视进展的生物标志物。
Nat Biomed Eng. 2023 Aug;7(8):986-1000. doi: 10.1038/s41551-023-01062-w. Epub 2023 Jun 26.
4
Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography.健康日本受试者脉络膜黑色素含量组织的偏振敏感光相干断层扫描评估。
Sci Rep. 2022 Mar 8;12(1):4048. doi: 10.1038/s41598-022-07818-9.
5
Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography.偏振敏感光学相干断层扫描测量黑素浓度和去极化度量。
Sci Rep. 2020 Nov 11;10(1):19513. doi: 10.1038/s41598-020-76397-4.
6
Photoprotection role of melanin in the human retinal pigment epithelium. Imaging techniques for retinal melanin.黑色素在人视网膜色素上皮中的光保护作用。视网膜黑色素的成像技术。
Rom J Ophthalmol. 2020 Apr-Jun;64(2):100-104.
7
Polarization-sensitive optical coherence tomography for estimating relative melanin content of autologous induced stem-cell derived retinal pigment epithelium.偏振敏感光学相干断层扫描估计自体诱导干细胞衍生视网膜色素上皮的相对黑色素含量。
Sci Rep. 2020 May 6;10(1):7656. doi: 10.1038/s41598-020-64601-4.
8
Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium.方向光学相干断层扫描揭示了视网膜色素上皮的黑色素浓度依赖性散射特性。
J Biomed Opt. 2019 Jun;24(6):1-10. doi: 10.1117/1.JBO.24.6.066011.
9
Clinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation.用于眼后段检查的色素和血流成像光学相干断层扫描临床原型。
Biomed Opt Express. 2018 Aug 20;9(9):4372-4389. doi: 10.1364/BOE.9.004372. eCollection 2018 Sep 1.
10
Imaging retinal melanin: a review of current technologies.视网膜黑色素成像：当前技术综述
J Biol Eng. 2018 Dec 4;12:29. doi: 10.1186/s13036-018-0124-5. eCollection 2018.