Makita Shuichi, Mino Toshihiro, Yamaguchi Tastuo, Miura Mashiro, Azuma Shinnosuke, Yasuno Yoshiaki
Computational Optics Group, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan.
Topcon Corporation, 75-1 Hasunumacho, Itabashi, Tokyo 174-8580, Japan.
Biomed Opt Express. 2018 Aug 20;9(9):4372-4389. doi: 10.1364/BOE.9.004372. eCollection 2018 Sep 1.
Measurements of the randomness of polarization (RP) obtained using polarization-sensitive optical coherence tomography (PS-OCT) are applied in several applications, and RP is attractive for posterior eye imaging. The addition of RP without retardation requires a minimal extension to standard OCT; therefore, we developed a prototype OCT system with a simplified scheme for RP measurement. A compact polarization-diversity receiver module is the only required hardware extension to a standard OCT system. All components were packed into the retinal scanning head. The degree-of-polarization uniformity and complex-decorrelation based OCT angiography were calculated using noise-corrected algorithms that accounted for the depth-dependent noise power. The structure, melanin, and blood flow distribution imaging of human eyes were demonstrated. Pathological eye imaging shows potential applications for combinations of these contrasts.
使用偏振敏感光学相干断层扫描（PS-OCT）获得的偏振随机性（RP）测量在多种应用中得到了应用，并且RP对于眼后段成像具有吸引力。在不增加延迟的情况下添加RP只需对标准OCT进行最小程度的扩展；因此，我们开发了一种具有简化RP测量方案的OCT原型系统。紧凑的偏振分集接收器模块是标准OCT系统唯一需要的硬件扩展。所有组件都封装在视网膜扫描头中。使用考虑了深度相关噪声功率的噪声校正算法计算偏振度均匀性和基于复去相关的OCT血管造影。展示了人眼的结构、黑色素和血流分布成像。病理性眼部成像显示了这些对比度组合的潜在应用。
